AI Article Synopsis
- A series of (E/Z)-Goniothalamin analogs were created from specific chemical compounds through a three-step process, resulting in varying levels of yield.
- Among these analogs, (Z)-Goniothalamin showed the highest cytotoxic effect against the Jurkat E6.1 T cell line, with an IC50 value of 12 μM.
- The study also found that modifications like changing the phenyl ring to other structures or altering the ring size did not enhance cytotoxicity.
Article Abstract
A series of six/five member (E/Z)-Goniothalamin analogs were synthesized from commercially available (3,4-dihydro-2H-pyran-2-yl)methanol/5-(hydroxymethyl)dihydrofuran-2(3H)-one in three steps with good to moderate overall yields and their cytotoxicity against lymphoblastic leukemic T cell line (Jurkat E6.1) have been evaluated. Among the synthesized analogs, (Z)-Goniothalamin appeared to be the most active in cytotoxicity (IC50 = 12 μM). Structure-activity relationship study indicates that introducing substituent in phenyl ring or replacing phenyl ring by pyridine/naphthalene, or decreasing the ring size of lactones (from six to five member) do not increase the cytotoxicity.
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| http://dx.doi.org/10.1007/s12272-013-0099-1 | DOI Listing |
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