A group of 21 patients with hydronephrosis but normal bladders had their upper urinary tract pressures monitored while perfusing the affected kidneys through a fine bore nephrostomy tube, initially with the bladder on free drainage and subsequently during bladder filling. In 7 patients the renal pelvic pressures were altered by bladder filling and loin pain was reproduced in 4. It was concluded that with high upper tract flow rates, vesical filling can affect upper tract dynamics and this should be considered when evaluating patients with loin pain or potential obstructive uropathy.
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Cureus
December 2024
Surgical Oncology, All India Institute of Medical Sciences, New Delhi, New Delhi, IND.
We report a rare case of adenosquamous carcinoma of the gall bladder (GB) causing portal vein tumor thrombus. A 40-year-old gentleman presented with acute-onset right upper abdominal pain. Ultrasonography revealed multiple calculi in the GB with wall thickening, suggesting acute cholecystitis.
View Article and Find Full Text PDFNeurourol Urodyn
January 2025
Department of Surgery, Division of Urology, Virginia Commonwealth University Health System, Richmond, Virginia, USA.
Introduction And Objective: Observable autonomous rhythmic changes in intravesical pressure, termed bladder wall micromotion, is a phenomenon that has been linked to urinary urgency, the key symptom in overactive bladder (OAB). However, the mechanism through which micromotion drives urinary urgency is poorly understood. In addition, micromotion is inherently difficult to study in human urodynamics due to challenges distinguishing it from normal cyclic physiologic processes such as pulse rate, breathing, rectal contractions, and ureteral jetting.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Department of Urology and Andrology, Collegium Medicum, Nicolaus Copernicus University, M. Curie Skłodowskiej 9, 85-094 Bydgoszcz, Poland.
Intravenous fluid management is integral to perioperative care, particularly under enhanced recovery after surgery (ERAS) protocols. In radical cystectomy (RC), which carries high risks of complications and mortality, optimizing fluid management poses a significant challenge due to the absence of definitive guidelines. the purpose of this study was to investigate the effects of intravenous fluid administration on postoperative complications in patients undergoing RC.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Physiology and Cell Biology, School of Medicine, University of Nevada Reno, Reno, NV 89557, USA.
The urothelium and lamina propria (LP) contribute to sensations of bladder fullness by releasing multiple mediators, including prostaglandins (PGs) and adenosine 5'-triphosphate (ATP), that activate or modulate functions of cells throughout the bladder wall. Mediators that are simultaneously released in response to bladder distention likely influence each other's mechanisms of release and action. This study investigated whether PGs could alter the extracellular hydrolysis of ATP by soluble nucleotidases (s-NTDs) released in the LP of nondistended or distended bladders.
View Article and Find Full Text PDFEur Urol Focus
January 2025
Department of Urology, University of Rennes, Rennes, France.
Background And Objective: Artificial urinary sphincter (AUS) is commonly used in France in female patients with stress urinary incontinence (SUI) due to intrinsic sphincter deficiency (ISD). However, it has never been assessed using patient-reported outcomes. This study aimed to evaluate the functional outcomes of robotic AUS implantation using validated questionnaires.
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