Five years ago, a 44 year-old woman presented with an apparently localized cancer of the right breast, initially treated by surgery, adjuvant chemotherapy and radiotherapy. After a 4 year disease-free interval, she developed bi-temporal hemianopsy, due to a suprasellar tumor causing compression of the optic chiasma. The tumor was resected by the transsphenoidal route and histological examination revealed neuroendocrine characteristics described as "argyrophilic breast carcinoma". The exceptional association of this peculiar histology for breast cancer with a rare pattern of recurrence (single pituitary metastasis) is worthwhile reporting.
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The value and significance of nucleolar organizer region proteins as markers of malignancy in breast cancer patients.
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From the Department of Clinical Laboratory Sciences (Salih, Dahlawi), College of Applied Medical Sciences, Taif University, Taif, from the Department of Medical Laboratory (Abdulgafor), King Faisal Special Hospital Research Center, Al-Madinah Al-Munawarah, and from the Department of Laboratory Medicine (Khalifa), Faculty of Applied Medical Science, University of Al Baha, Al Baha, Kingdom of Saudi Arabia.
Objectives: To assess argyrophilic nucleolar organizer regions (AgNORs) in 60 patients with primary breast carcinoma and evaluated their association with clinical prognostic parameters of breast cancer.
Methods: Argyrophilic nucleolar organizer regions were stained in paraffin sections of the tissues using Ploton's silver method. For each sample, the number of AgNORs within the nuclei of 100 tumor cells was counted.
The detection of pomegranate ( L.) peel apoptotic effects using AgNOR staining in MDA-MB-231.
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February 2024
Department of Nutrition and Dietetics, Faculty of Health Sciences, University of Nuh Naci Yazgan, Ertuğrul Gazi district, Nuh Naci Yazgan Campus, Küme Evler Kocasinan, Kayseri 38090, Turkey.
In present study, it was purposed to determine the in vitro effect of the extract obtained from the pomegranate ( L.) peel on the breast cancer cell line. MDA-MB-231 cells were exposed to pomegranate peel extract (PoPx) at 37 °C and 5% CO for varying durations (24 and 48 h) and doses (25 and 50 μg/mL).
View Article and Find Full Text PDFAssociation of Proliferative Indices With Various Grades of Breast Carcinoma.
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Department of Pathology, Teerthanker Mahaveer Medical College, Moradabad, IND.
Aims And Objectives: Various grades of breast carcinoma and proliferative indices used as nuclear protein Ki-67 and argyrophilic nucleolar organizer regions (AgNOR) are being compared to each other.
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New Derivatives from Microbial Transformation of ent-Kaur-16-en-19-oic Acid by Cunninghamella echinulata.
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View Article and Find Full Text PDFBackground: Apart from a number of cases of inaccurate prognosis in regard to individual patients, the inter- and intra-observer variability of the classical, histological prognosis parameters have been under repeated discussion. For this reason, a long-term analysis was carried out in regard to overall survival by means of automated microscopic image analysis of the nucleolar organizer regions (AgNORs) to objectify tumour grading in the case of breast carcinoma.This consists of a selective representation of argyrophilic proteins that are associated with the nucleolus organising regions.
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