At a histochemical investigation of the rabbit lymphoid organs innervation certain peculiarities on histotopography of adrenergic and acetylcholinesterase (AChE)-containing nervous elements have been established. At a chronic experiment by means of a dosed repeated bilateral electrostimulation of the posterior hypothalamic field in the organs mentioned, inhibition of the functional activity has been noticed. It is most specific not for the AChE-containing structures, but for the adrenergic ones, localized to some extent in the parenchyma, as well as along the course of the blood vessels and their adventitium. The results are discussed in terms of modulatory influence of the posterior hypothalamic field on trophic and functions of the lymphoid tissue. This influence is realized both humoraly and via the nervous pathways (either directly using certain ways and connections, or indirectly by means of neurogenic tonus of the intraorganic blood vessels regulation).
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Inflamm Res
January 2025
Medical Faculty and University Hospital, Institute of Neural and Sensory Physiology, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
Background: Adenosine, an ATP degradation product, is a sleep pressure factor. The adenosine 1 receptor (A1R) reports sleep need. Histaminergic neurons (HN) of the tuberomamillary nucleus (TMN) fire exclusively during wakefulness and promote arousal.
View Article and Find Full Text PDFBrain Struct Funct
January 2025
Department of Physiology and Neurobiology, Laboratory of Molecular and Systems Neurobiology, Eötvös Loránd University, Budapest, Hungary.
The lateral septum (LS) demonstrates activation in response to pup exposure in mothers, and its lesions eliminate maternal behaviors suggesting it is part of the maternal brain circuitry. This study shows that the density of pup-activated neurons in the ventral subdivision of the LS (LSv) is nearly equivalent to that in the medial preoptic area (MPOA), the major regulatory site of maternal behavior in rat dams. However, when somatosensory inputs including suckling were not allowed, pup-activation was markedly reduced in the LSv.
View Article and Find Full Text PDFJ Neurophysiol
January 2025
Department of Foundational Sciences and Humanities, Discipline of Cellular & Molecular Pharmacology, Rosalind Franklin University, North Chicago, IL, USA, 60064.
The medial amygdala (MeA) is activated by social stimuli and manipulations of the MeA disrupt a wide range of social behaviors. Social stress can shift social behaviors and may accomplish this partly via effects on the MeA. However, very little is known about the effects of social stress on the electrophysiological activity of MeA neurons.
View Article and Find Full Text PDFPituitary
December 2024
Department of Diabetes and Endocrinology, St Vincent's Hospital Sydney, Darlinghurst, NSW, Australia.
Purpose: Rathke's cleft cysts (RCC) are present in up to 20% of autopsy studies but only a minority necessitate surgical treatment. Inflammation of RCC is thought to be significant in three processes: the development of classical symptoms, a predisposition to rupture or apoplexy, and increasing the rate of RCC recurrence. We aim to characterize clinical presentation, histological and radiological findings in patients with surgically managed RCC.
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