Interferon alpha (IFNα) has immune stimulatory actions implicated in its pulmonary toxicities. We describe deterioration of idiopathic pulmonary fibrosis (IPF) associated with IFNα treatment for chronic hepatitis C in a 58 year old woman culminating in a fatal suspected acute exacerbation of IPF (AE-IPF). Caution should be exercised in the use of IFNα in subjects with concomitant IPF given its known immunostimulatory effects and possible role in this suspected AE-IPF.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606512 | PMC |
| http://dx.doi.org/10.1186/2193-1801-2-101 | DOI Listing |
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