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Causal associations between immune cells and psychiatric disorders: a bidirectional mendelian randomization analysis.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Graduate School of PLA Medical College, Chinese PLA General Hospital and PLA Medical College, 28 Fu Xing Road, Beijing, 100083, China.
Extensive researches illuminate a potential interplay between immune traits and psychiatric disorders. However, whether there is the causal relationship between the two remains an unresolved question. We conducted a two-sample bidirectional mendelian randomization by utilizing summary data of 731 immune cell traits from genome-wide association studies (GCST90001391-GCST90002121)) and 11 psychiatric disorders including attention deficit/hyperactivity disorder (ADHD), anxiety disorder, autism spectrum disorder (ASD), bipolar disorder (BIP), anorexia nervosa (AN), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), Tourette syndrome (TS), post-traumatic stress disorder (PTSD), schizophrenia (SCZ), and substance use disorders (cannabis) (SUD) from the Psychiatric Genomics Consortium (PGC).
View Article and Find Full Text PDFCausal associations between childhood obesity and delayed puberty or height: a bidirectional two-sample Mendelian randomization study.
J Pediatr Endocrinol Metab
January 2025
Department of Pediatric Endocrinology, School of Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Objectives: Childhood obesity is thought to influence pubertal development, according to observational studies. However, the exact causal relationship remains unclear due to the complexity of factors affecting pubertal development.
Methods: To explore the association between exposure (childhood obesity) and outcome (delayed puberty, height), we utilized various methods, including inverse-variance weighted (IVW), weighted median, weighted mode, and MR Egger regression.
Evaluation of the utility of the sFlt-1/PlGF ratio in pregnancy complicated by pre-eclampsia - single-center study. Preliminary analysis.
Ginekol Pol
January 2025
Department of Obstetrics and Perinatology, Jagiellonian University Medical College, Cracow, Poland, Poland.
Objectives: To evaluate relationship between sFlt-1/PlGF ratio, clinical characteristics and outcomes of pre-eclampsia.
Material And Methods: Retrospective analysis of 29 pregnant women with pre-eclampsia who had measured sFlt-1/PlGF ratio was conducted using electronic medical records from Obstetrics and Perinatology ward of University Hospital in Cracow.
Results: Women median age: 33.
Family Size across the Life Course and Cognitive Decline in Older Mexican Adults.
J Gerontol B Psychol Sci Soc Sci
January 2025
College of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Objectives: A growing body of research has identified associations between family size and cognition in older adults. These studies largely focus on older adults' own fertility history instead of sibship size, defined as one's number of siblings. Sibship size may impact cognitive development during early childhood, creating differences that may persist into late-life.
View Article and Find Full Text PDFBirth Rate as a Determinant of Dementia Incidence: A Comprehensive Global Analysis.
Am J Alzheimers Dis Other Demen
January 2025
Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.
Background: The role of parity in predicting dementia risk in women is debated. This study examines how birth rate affects global dementia incidence.
Methods: Country-specific data on birth rate and dementia incidence rate were analyzed using bivariate analysis, partial correlation, and multiple linear regression.
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