AI Article Synopsis
- Diabetes mellitus leads to high blood sugar levels due to issues with insulin, and it can negatively affect the brain, causing conditions like diabetic encephalopathy and depression.
- There is a higher rate of depression in diabetics compared to the general population, and clonazepam is used to help treat this issue alongside insulin therapy.
- Research on diabetic rats showed that those treated with insulin and clonazepam had less DNA and lipid damage in brain areas linked to depression, suggesting these treatments might provide neuroprotective effects.
Article Abstract
Diabetes mellitus is characterized by hyperglycemia resulting from defects on insulin secretion, insulin action, or both. It has recently become clear that the central nervous system is not spared from the deleterious effects of diabetes, since diabetic encephalopathy was recognized as a complication of this heterogeneous metabolic disorder. There is a well recognized association between depression and diabetes, once prevalence of depression in diabetic patients is higher than in general population, and clonazepam is being used to treat this complication. Oxidative stress is widely accepted as playing a key mediatory role in the development and progression of diabetes and its complications. In this work we analyzed DNA damage by comet assay and lipid damage in prefrontal cortex, hippocampus and striatum of streptozotocin-induced diabetic rats submitted to the forced swimming test. It was verified that the diabetic group presented DNA and lipid damage in the brain areas evaluated, when compared to the control groups. Additionally, a significant reduction of the DNA and lipid damage in animals treated with insulin and/or clonazepam was observed. These data suggest that the association of these two drugs could protect against DNA and lipid damage in diabetic rats submitted to the forced swimming test, an animal model of depression.
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| http://dx.doi.org/10.1007/s11011-013-9397-z | DOI Listing |
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