*Division of Histological and Clinical Pathology, Hualian Army Forces General Hospital, Hualien †Department of Pathology, Tri-Service General Hospital, National Defense Medical Center ‡Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei §Department of Pathology, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan, ROC.
Published: April 2014
AI Article Synopsis
Article Abstract
Gastric adenocarcinoma is a lethal disease with high incidence in Chinese people. The purpose of this study was to evaluate the expression of urocortin (UCN) in normal gastric mucosa and gastric adenocarcinomas. Immunohistochemical analysis of UCN was performed in 112 surgical specimens (21 normal gastric mucosa specimens and 91 gastric adenocarcinoma specimens varying in histologic grade and pathologic stage). Immunostain intensity was scored on a scale ranging from 0 (absence of staining) to 3 (strong staining). The percentage of UCN stained cells was scored on a scale ranging from 0 (<5%) to 4 (75% to 100%). The UCN immunoscore (ranging from 0 to 12) was the product of the above 2 scores. The UCN immunoscore was high in all 9 normal gastric mucosa specimens, significantly lower in poorly differentiated gastric adenocarcinoma than in well and moderately differentiated tumors (P=0.018), and significantly lower in more advanced pathologic stages of gastric adenocarcinomas than in the early stages of these tumors. Moreover, UCN expression was higher in gastric adenocarcinomas with neuroendocrine differentiation than in mucinous adenocarcinomas and signet-ring cell carcinomas. In conclusion, UCN is expressed in most non-neoplastic gastric glandular epithelia. However, UCN expression inversely correlates with higher tumor grade and advanced TNM stage in gastric adenocarcinomas.
State Key Laboratory of Bioactive Molecules and Druggability Assessment, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE) of China, School of Pharmacy, Jinan University, Guangzhou, China.
Background: Stomach adenocarcinoma (STAD) is an aggressive malignancy characterized by high tumor plasticity and heterogeneity. This study investigates the role of Autophagy and Beclin 1 Regulator 1 (AMBRA1) in regulating tumor plasticity in STAD progression.
Methods: Combined with clinical data, the pan-cancer analysis of AMBRA1 was performed to analyze the role of AMBRA1 in STAD.
A 54-year-old man presented with constipation with a six-month duration and a 5 kg weight loss over 10 months. He had undergone a subtotal gastrectomy and chemotherapy for advanced gastric cancer 13 years earlier. A colonoscopy revealed a firm, circular, in-growing mass in the rectum.
Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
The prevalence of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in Korea has not been reported largely because, it is a relatively rare disease. Gastric MALT lymphoma is clinically important because of the high prevalence of () in Korea. The endoscopic findings of gastric MALT lymphoma are diverse, and it is often challenging to differentiate from gastric adenocarcinoma.
In pathological examinations, gastric ulcers are often detected in South American camelids. The aetiology cannot be clarified in every case. However, tumour-related gastric ulcers are observed repeatedly.
Background: Linitis plastica is a challenging diagnosis in the setting of a patient with previous breast cancer.
Case Presentation: We present a case of a 74-year-old Chinese Female with a history of breast cancer who presented with epigastric pain, nausea, early satiety, and weight loss of 5 kg in 3 months. Endoscopic diagnosis of linitis plastica was made, but subsequent management plans were dependent on accurate histological assessment in view of her oncological history.
