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BMAL1 improves assisted reproductive technology outcomes in patients with polycystic ovary syndrome by targeting BMP6 and regulating ovarian granulosa cell apoptosis.
J Assist Reprod Genet
January 2025
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, Shandong, China.
Purpose: To investigate BMAL1 and BMP6 expressive differences in ovarian granulosa cells (OGCs) of patients with polycystic ovary syndrome (PCOS), explore regulatory relationship, assess their impacts on OGC proliferation and apoptosis, and analyze their correlations with ART outcomes of patients.
Methods: A clinical study selected 40 PCOS patients who underwent IVF/ICSI in our hospital from January to October 2022 and 39 controls with male or tubal factor infertility. RT-qPCR and Western blot assessed BMAL1 and BMP6 mRNA/protein levels.
Sisonke Ntwana: Describing the mechanisms of change of an arts-based intervention for pregnant and parenting adolescents experiencing violence and poor mental health in South Africa.
Child Abuse Negl
January 2025
School of Public Health, University of the Witwatersrand, Johannesburg, South Africa; Gillings School of Global Public Health, University North Carolina, USA.
Background: In South Africa, one in five adolescents experience pregnancy and face heightened rates of interpersonal violence and mental health challenges. Yet, few interventions are tailored to them.
Methods: 28 pregnant adolescents reporting past year intimate partner violence and/or non-partner rape were purposively recruited in antenatal clinics in Johannesburg to attend a 6-session arts-based intervention, delivered by 4 graduate art therapy students alongside clinical supervision.
Lesion classification and diabetic retinopathy grading by integrating softmax and pooling operators into vision transformer.
Front Public Health
January 2025
Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Introduction: Diabetic retinopathy grading plays a vital role in the diagnosis and treatment of patients. In practice, this task mainly relies on manual inspection using human visual system. However, the human visual system-based screening process is labor-intensive, time-consuming, and error-prone.
View Article and Find Full Text PDFProtocol for a mixed-methods randomised controlled trial evaluating the psychosocial effects of an expressive arts-based intervention on adults with age-related macular degeneration.
BMJ Open
December 2024
Department of Psychiatry, University of Hong Kong, Hong Kong, China.
Introduction: Age-related macular degeneration (AMD) is a prevalent eye disease among middle-aged and older adults. AMD leaves the patient with irreversible deteriorating vision, which profoundly impacts their daily lives and psychosocial well-being. Given the limited studies addressing the psychosocial needs of adults with AMD and, in particular, using an expressive arts-based intervention (EXABI) as an intervention, this study aims to investigate the effectiveness of such an intervention in enhancing the psychosocial well-being of adults with AMD.
View Article and Find Full Text PDFA discrete convolutional network for entity relation extraction.
Neural Netw
January 2025
State Key Laboratory of Public Big Data, Guizhou University, 550025, China; Engineering Research Center of Text Computing & Cognitive Intelligence, Ministry of Education, Guizhou University, 550025, China; College of Computer Science and Technology, Guizhou University, 550025, China. Electronic address:
Relation extraction independently verifies all entity pairs in a sentence to identify predefined relationships between named entities. Because these entity pairs share the same contextual features of a sentence, they lead to a complicated semantic structure. To distinguish semantic expressions between relation instances, manually designed rules or elaborate deep architectures are usually applied to learn task-relevant representations.
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