AI Article Synopsis

  • The study investigates the relationship between red cell distribution width (RDW) and renal function in kidney transplant recipients, finding that lower glomerular filtration rate (eGFR) is linked to higher RDW.
  • The analysis involved 723 kidney transplant patients not on erythropoietin-stimulating agents, controlling for factors like age, sex, comorbidities, blood levels, and inflammation markers.
  • Results indicate that a 10 ml/min reduction in eGFR correlates with increased RDW values, irrespective of other health indicators, suggesting impaired renal function affects red blood cell size variability in these patients.

Article Abstract

Red cell distribution width (RDW), a measure of heterogeneity in the size of circulating erythrocytes, reportedly predicts mortality. Similarly to RDW, impaired renal function is also associated with inflammation and protein-energy wasting. This study assessed if renal function is associated with RDW independent of relevant confounders in stable kidney transplant recipients. We examined the association between RDW and estimated glomerular filtration rate (eGFR) in a cohort of 723 prevalent kidney transplanted recipients who were not receiving erythropoietin-stimulating agents. Associations were examined in regression models adjusted for age, sex, comorbidity, blood haemoglobin, iron indices, markers of nutritional status and inflammation, markers of bone and mineral metabolism and the use of immune suppressants. Lower eGFR was significantly associated with higher RDW (r = -0·382, P < 0·001). This association remained highly significant even after multivariate adjustments where 10 ml/min decrease in the eGFR was significantly associated with an increase of the RDW values (B10 ml/min decrease  =  0·078; 95% confidence interval: 0·044-0·111). The results were consistent in subgroups of patients with different levels of haemoglobin, chronic kidney disease status and various markers of inflammation and iron status. Lower eGFR is associated with higher RDW, independent of comorbidity, iron deficiency, inflammation and nutritional status in kidney transplant recipients.

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Source
http://dx.doi.org/10.1111/bjh.12315DOI Listing

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