AI Article Synopsis
- A new triterpene glycoside called agroastragaloside V was discovered in the roots of Astragalus membranaceus and its structure was determined using advanced spectroscopic techniques.
- Four previously known cycloartane glycosides were also isolated during this study.
- The compounds were evaluated for their effectiveness in reducing LPS-induced nitric oxide production in macrophage cells, which is important for understanding their potential anti-inflammatory properties.
Article Abstract
A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure was identified as 3-O-β-(2'-O-acetyl)-D-xylopyranosyl-6-O-β-D-glucopyranosyl-(24S)-3β,6α,24α,25-tetrahydroxy- 9,19-cyclolanostane, by means of spectroscopic methods, including HR-FAB/MS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. Four known cycloartane glycosides, namely, agroastragaloside I (2), agroastragaloside II (3), isoastragaloside II (4) and astragaloside IV (5) were also isolated. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269660 | PMC |
| http://dx.doi.org/10.3390/molecules18043725 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Protective effects of methylnissolin and methylnissolin-3-O-β-d-glucopyranoside on TNF-α-induced inflammation in human dermal fibroblasts.
Toxicol In Vitro
December 2024
Department of Preventive Medicine, College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea. Electronic address:
Methylnissolin-3-O-β-d-glucopyranoside (MNG) and methylnissolin (MN) are pterocarpan derivatives that are found in plants, such as Astragalus membranaceus. There are limited existing studies on the potential health benefits of MNG, and currently there is no evidence to suggest that MNG has any impact on skin-aging. Tumor necrosis factor-alpha (TNF-α) plays a significant role in skin aging by promoting chronic inflammation, damaging skin cells, and impairing the skin's natural repair mechanisms.
View Article and Find Full Text PDFExploratory review on the effect of on signaling pathways.
Front Pharmacol
December 2024
Department of Cardiology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, China.
Background: Bunge [Fabaceae; ] (AM), a traditional Chinese medicinal (TCM) botanical drug, has been used for centuries and is gaining growing recognition in medical research for its therapeutic potential. The currently accepted scientific name is Astragalus mongholicus Bunge, with Astragalus membranaceus Fisch. ex Bunge recognized as a taxonomic synonym.
View Article and Find Full Text PDFPredicting the potential distribution of Astragali Radix in China under climate change adopting the MaxEnt model.
Front Plant Sci
December 2024
School of Public Health, Shandong Second Medical University, Weifang, China.
Introduction: Astragali Radix is the dried root of Astragalus mongoliae or Astragalus membranaceus, a leguminous plant. Since ancient times, Astragali Radix has been widely used in Chinese traditional Chinese medicine. As people become more health-conscious, the market demand for Astragali Radix grows and its popularity is increasing in the international market.
View Article and Find Full Text PDFInvestigation of the Potential Material Basis and Mechanism of Astragali Radix Against Adriamycin-Induced Nephropathy Model Rat by H NMR and MS-Based Untargeted Metabolomics Analysis.
Biomed Chromatogr
January 2025
Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, China.
Astragali Radix (AR) is one of the monarch drugs of Fangji Huangqi decoction and has the effects of inducing diuresis to alleviate edema, tonifying and strengthening the body. However, there is a paucity of research regarding the effective fraction and the underlying metabolic mechanism of AR on nephrotic syndrome (NS). This work aims to elucidate the potential mechanisms of AR treating NS, as well as to identify effective part and components.
View Article and Find Full Text PDF[Rapid identification of honey-processing degree of Astragali Radix based on intelligent sensory technology and multivariate statistical analyses].
Zhongguo Zhong Yao Za Zhi
October 2024
School of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China.
To analyze the differences and dynamic changes in the color, odor, and major chemical components of Astragali Radix during honey processing, this study used a CM-5 spectrophotometer and Hercules NEO ultra-fast gas phase electronic nose for analysis. High performance liquid chromatography was employed to determine the content of calycosin, calycosin-7-glucoside, formononetin, and ononin in the Astragali Radix decoction pieces processed with honey to different degrees. Multivariate statistical analyses including partial least squares-discriminant analysis(PLS-DA), orthogonal partial least squares-discriminant analysis(OPLS-DA), differential factor analysis(DFA), and Bayesian discriminant analysis were adopted to differentiate the Astragali Radix decoction pieces processed with honey to different degrees and evaluate the correlations between visual characteristics and chemical composition.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!