We computationally and experimentally showed that tau protein fibrils can be formed at high temperature. When cooled, the fibrils dissociate back to monomers. Heparin promotes tau fibril formation and prevents its reversion. Our results revealed the physicochemical mechanism of reversible formation of tau fibrils.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637047 | PMC |
| http://dx.doi.org/10.1039/c3cc00241a | DOI Listing |
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