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http://dx.doi.org/10.1002/ajh.23442 | DOI Listing |
J Cardiovasc Echogr
April 2020
Cardiology Department, Hospital 'Bianchi Melacrino Morelli' Reggio Calabria, Italy.
Peripheral artery disease (PAD) and stroke can occur as vascular complication of anticancer treatment. Although the mechanisms, monitoring, and management of cardiotoxicities have received broad attention, vascular toxicities remain often underrecognized. In addition, the development of new chemotherapeutic drugs bears the risk of vasotoxicities that are yet to be identified and may not be realized with short-term follow-up periods.
View Article and Find Full Text PDFInt J Clin Pharm
February 2021
School of Pharmaceutical Sciences, Universiti Saints Malaysia, Gelugor, Penang, Malaysia.
Background Tyrosine kinase inhibitors have been demonstrated to improve the survival of patients with chronic myeloid leukaemia. However, medication adherence is vital for patients on chronic treatment. Objective The objective of the current study was to evaluate response to treatment, adherence by patients to tyrosine kinase inhibitors and factors associated with adherence and response.
View Article and Find Full Text PDFJ Neurointerv Surg
November 2018
Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, US.
Tyrosine kinase inhibitor (TKI) therapy for chronic myeloid leukemia (CML) has been associated with progressive peripheral arterial disease and, more recently, rare cases of intracranial vascular stenosis have been reported. We report the fourth case of TKI treatment associated intracranial vasculopathy and rapid progression of intracranial vascular stenosis following intracranial stent placement. This was a 49-year-old woman who developed right-sided weakness, paresthesias, numbness, and speech difficulties 7 years following TKI treatment for CML.
View Article and Find Full Text PDFInterv Neuroradiol
October 2017
1 Department of Neurosurgery, Osaka International Cancer Institute, Japan.
One of the second-generation tyrosine kinase inhibitors (TKIs), nilotinib, is increasingly used for imatinib-resistant or intolerant chronic myeloid leukemia (CML). Nilotinib is considered well tolerated with few side effects including hyperglycemia, hyperbilirubinemia and elevated levels of pancreatic enzymes. However, there is growing evidence that nilotinib accelerates atherosclerosis and causes peripheral arterial occlusive disease such as stroke, transient ischemic attack (TIA) and cardiovascular diseases.
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