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Role of c-MYC in tumor-associated macrophages and cancer progression. | LitMetric

Role of c-MYC in tumor-associated macrophages and cancer progression.

Oncoimmunology

Laboratory of Molecular and Genetic Cardiovascular Pathophysiology; Department of Epidemiology, Atherothrombosis and Imaging; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC); Madrid, Spain.

Published: February 2013

Transcription factors of the MYC family regulate several homeostatic cell functions, and their role as proto-oncogenes has been the focus of interest for decades. We have recently demonstrated that c-MYC is expressed by tumor-associated macrophages (TAMs) and regulates their phenotype and pro-tumor activities in vivo

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601167PMC
http://dx.doi.org/10.4161/onci.22984DOI Listing

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