A new manzamine-related alkaloid with unprecedented δ-lactone and ε-lactam rings called acantholactone (), was isolated from the Indonesian sponge sp. The relative configuration of the two new ring systems was established through detailed analysis of NOESY correlations combined with molecular modeling studies. The absolute configuration of was determined as 12, 24, 25, 26 by comparing the computed electronic circular dichroism (ECD) spectra with experimental values.
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| http://dx.doi.org/10.1016/j.tetlet.2012.08.140 | DOI Listing |
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