Effects of parasitism on cellular immune response in sheep experimentally infected with Haemonchus contortus.

Vet Parasitol

Department of Clinical Science, College of Veterinary Medicine, University of de São Paulo, Av. Prof. Orlando Marques de Paiva, 87, Cidade Universitária, 05508-270 São Paulo - SP, Brazil.

Published: September 2013

AI Article Synopsis

  • This study investigated the relationship between abomasal worm burden from Haemonchus contortus and immune responses in lambs, focusing on leucocyte and mast cell proliferation.
  • Eighteen Suffolk × Greyface lambs were examined, with half infected and half uninfected, and blood samples were analyzed over time to track changes in white blood cell counts.
  • Results showed that higher parasite loads were associated with lower overall leucocyte counts and specific reductions in lymphocytes, neutrophils, and eosinophils, while lower worm burdens correlated with increased levels of mucosal mast cells and globular leucocytes.

Article Abstract

This work aimed to study the possible relationships among the magnitude of abomasal worm burden and the proliferation of globular leucocytes and mucosal mast cells in the abomasal mucosa, and the white blood cell count. Eighteen Suffolk × Greyface lambs were infected with Haemonchus contortus, and 12 were kept free of nematodes. Blood samples were collected on days 0, 30, and 57 post-infection (p.i.) for leucogram determination. At day 62, all animals were euthanized to count the total number of nematodes recovered in the abomasum and to count the number of mucosal mast cells and globular leucocytes. On day 57, higher levels of parasitism corresponded to lower leucocyte counts. The infected groups had lower lymphocyte counts throughout the experimental period. Animals with higher numbers of parasites had lower neutrophil and eosinophil counts on day 57. The lower the worm burden, the greater the number of mucosal mast cells (r=-0.85; p<0.01) and globular leucocytes (r=-0.87, p<0.01) observed. The sheep most resistant to haemochosis had greater peripheral and tissue cellular immune responses.

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http://dx.doi.org/10.1016/j.vetpar.2013.02.014DOI Listing

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