Early detection of non blanching erythema (pressure ulcer category I) is necessary to prevent any further skin damage. An objective method to discriminate between blanching/non blanching erythema is presently not available. The purpose of this investigation was to explore if a non invasive objective method could differentiate between blanching/non blanching erythema in the sacral area of patients undergoing hip fracture surgery. Seventy-eight patients were included. The sacral area of all patients was assessed using (i) conventional finger-press test and (ii) digital reading of the erythema index assessed with reflectance spectrophotometry. The patients were examined at admission and during 5 days postsurgery. Reflectance spectrophotometry measurements proved able to discriminate between blanching/non blanching erythema. The reliability, quantified by the intra-class correlation coefficient, was excellent between repeated measurements over the measurement period, varying between 0·82 and 0·96, and a significant change was recorded in the areas from day 1 to day 5 (P < 0·0001). The value from the reference point did not show any significant changes over the same period (P = 0·32). An objective method proven to identify early pressure damage to tissue can be a valuable tool in clinical practice.
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http://dx.doi.org/10.1111/iwj.12044 | DOI Listing |
J Wound Ostomy Continence Nurs
November 2024
Caroline Borzdynski, BN(Hons), RN, PhD candidate, La Trobe University, Bundoora, Victoria, Australia.
Cutis
May 2024
Mishma Farsi is from the Medical College of Georgia, Augusta. Dr. Gray is from The Ohio State University Wexner Medical Center, Columbus. Dr. Segars is from Kaiser Permanente Olympia Medical Center, Washington.
J Addict Med
October 2024
From the Department of General Internal Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (CT, VL, JM, JT, JB); and Grayken Center for Addiction, Boston Medical Center, Boston, MA, Boston, MA (JT).
Introduction: Extended-release subcutaneous buprenorphine is an increasingly common treatment for opioid use disorder. Serious adverse events are rare and may be poorly understood. This report describes an early surgical intervention to address tissue necrosis resulting from misplaced subcutaneous buprenorphine injection.
View Article and Find Full Text PDFSci Rep
November 2023
Department of Molecular Pathology, Graduate School of Medical Sciences, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Early pressure injury (PI) progression is associated with multi-circulatory disorders and they interplay with each other, resulting in a lack of a satisfactory diagnostic method. We generated early PI and blanchable erythema hairless rat models. Transparent disc method and capillary refilling time test (CRTT) results were recorded with ultraviolet camera to capture the dynamics changes, and the blanching index and refilling index were set for comprehensive analysis.
View Article and Find Full Text PDFBMC Pharmacol Toxicol
October 2023
Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, 210042, Jiangsu, China.
Background: EMLA cream is a local anesthetic. The pharmacokinetics and dermal effects of a topical anesthetic formulation has not been evaluated in healthy Chinese volunteers.
Materials And Methods: The Pharmacokinetics of the lidocaine/prilocaine test (T) or reference (R, EMLA) cream were evaluated in a fasting, single-dose, two-period crossover bioequivalent study conducted in 40 healthy Chinese volunteers.
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