Objective: To compare the malposition rates of endotracheal tubes (ETTs) when the insertional length (IL) is determined by a weight-based nomogram versus when IL is determined by palpation of the ETT tip.
Design: Open-label, randomized controlled trial (RCT).
Setting: Level III neonatal intensive care unit (NICU).
Subjects: All newborn babies admitted in NICU requiring intubation.
Interventions: Subjects were randomly allocated to one of three groups, wherein IL was determined by (i) weight-based nomogram alone, (ii) weight-based nomogram combined with suprasternal palpation of ETT tip performed by specially trained neonatology fellows, or (iii) combination of weight-based and suprasternal methods by personnel not specially trained.
Primary Outcome: Rate of malposition of ETT as judged on chest X-ray (CXR).
Results: Fifty seven babies were randomized into group 1(n = 15), group 2 (n = 20), and group 3 (n = 22). The proportion of correct ETT placement was highest in group 2, being 66.7%, 83.3%, and 66.7% in groups 1 through 3, respectively (P value = 0.58). No complication was attributable to palpation technique.
Conclusion: Suprasternal palpation shows promise as a simple, safe, and teachable method of confirming ETT position in neonates.
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http://dx.doi.org/10.1111/pan.12147 | DOI Listing |
J Perinatol
September 2024
Division of Pediatrics and Neonatal Critical Care, "A. Béclère" Medical Center, Paris-Saclay University Hospitals, APHP, Paris, France.
Objective: Scanty data are available about neonatal systemic vascular resistances (SVR). We aim to provide reference values and nomograms for neonatal SVR.
Design: Multicenter, cross-sectional,descriptive study performed in France and Italy.
Antimicrob Agents Chemother
April 2024
Merck & Co., Inc., Rahway, New Jersey, USA.
The objective of this study was to support posaconazole dose regimens in pediatric patients aged ≥2 years, using a population pharmacokinetic (PK) approach with data from a phase 1b study (NCT02452034). A one-compartment model with first-order absorption was fit to pharmacokinetic data from 144 participants aged 2 to 17 years, who were administered posaconazole as intravenous (IV) and powder for oral suspension (PFS) formulations, or IV only, at dosing regimens of 3.5, 4.
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September 2024
Division of Hematology, Brigham and Women's Hospital, Boston, MA.
Introduction: Brigham and Women's Hospital historically used titratable weight-based heparin nomograms with as needed boluses managed by extracorporeal membrane oxygenation specialists to achieve a predetermined goal-activated partial thromboplastin time (aPTT). Due to concern amongst providers that as needed boluses may lead to supratherapeutic aPTT's and subsequent bleeding, new nomograms without as needed boluses were implemented. The purpose of this retrospective observational analysis is to provide a comparison in safety and efficacy between the heparin nomograms with as needed boluses and the new nomograms without boluses.
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Global Medical Office, Haemonetics Corporation, Boston, Massachusetts, USA.
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View Article and Find Full Text PDFNutr Clin Pract
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School of Health and Rehabilitation Science, The Ohio State University, Columbus, Ohio, USA.
Background: Nutrition support professionals are tasked with estimating energy requirements for critically ill patients. Estimating energy leads to suboptimal feeding practices and adverse outcomes. Indirect calorimetry (IC) is the gold standard for determining energy expenditure.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!