Background: Rapid eye movement (REM) sleep behavior disorder (RBD) is present in around 40% of Parkinson's disease (PD) patients. Definitive diagnosis requires a polysomnogram, but that is costly, time intensive, and not practical for large-scale studies. Therefore, we assessed using a questionnaire-based diagnostic approach.
Methods: The patient-administered RBD questionnaire and bed-partner-administered question 1 of the Mayo questionnaire were prospectively validated.
Results: Seventy-five PD patients (51 male, 68 Hoehn and Yahr stages I and II) participated. Forty-eight had a clinical history of RBD. Sensitivity was 100% (95% CI, 86.3%-100%) when a combination of both questionnaires was compared with the gold standard of polysomnogram-confirmed RBD. Among those who achieved REM sleep (n=65), specificity was highest for the patient questionnaire used alone, at 82.4% (95% CI, 64.8%-92.6%).
Conclusions: A combination of patient and bed-partner questionnaires is a useful tool to detect RBD.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/mds.25438 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Calcineurin governs baseline and homeostatic regulations of non-rapid eye movement sleep in mice.
Proc Natl Acad Sci U S A
January 2025
National Institute of Biological Sciences, Beijing 102206, China.
Sleep need accumulates during waking and dissipates during sleep to maintain sleep homeostasis (process S). Besides the regulation of daily (baseline) sleep amount, homeostatic sleep regulation commonly refers to the universal phenomenon that sleep deprivation (SD) causes an increase of sleep need, hence, the amount and intensity of subsequent recovery sleep. The central regulators and signaling pathways that govern the baseline and homeostatic sleep regulations in mammals remain unclear.
View Article and Find Full Text PDFBreathtaking dreams: reduced REM phenotype in REM-related sleep apnea.
Sleep Breath
January 2025
Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Purpose: The expression of the respiratory events in OSA is influenced by different mechanisms. In particular, REM sleep can highly increase the occurrence of events in a subset of OSA patients, a condition dubbed REM-OSA (often defined as an AHI 2 times higher in REM than NREM sleep). However, a proper characterization of REM-OSA and its pathological sequelae is still inadequate, partly because of limitations in the current definitions.
View Article and Find Full Text PDFThe relationship between chronic ankle instability and sleep behaviour.
Res Sports Med
January 2025
School of Health and Kinesiology, University of Nebraska Omaha, Omaha, USA.
Chronic Ankle Instability (CAI) is a condition characterized by giving-way episodes, instability and recurrent ankle sprains. Poor sleep can increase the risk of musculoskeletal injury and sleep is known to be an important aspect of injury recovery. However, the effect sleep has on those with CAI as well as its risk for recurrent episodes of giving-way remains unclear.
View Article and Find Full Text PDFComprehensive assessment reveals numerous clinical and neurophysiological differences between MECP2-allelic disorders.
Ann Clin Transl Neurol
January 2025
Section of Pediatric Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, 77030, USA.
Objective: Rett syndrome (RTT) and MECP2 duplication syndrome (MDS) result from under- and overexpression of MECP2, respectively. Preclinical studies using genetic-based treatment showed robust phenotype recovery for both MDS and RTT. However, there is a risk of converting MDS to RTT, or vice versa, if accurate MeCP2 levels are not achieved.
View Article and Find Full Text PDFValidation of a novel mask-based device for monitoring of comprehensive sleep parameters and sleep disordered breathing.
Sleep Breath
January 2025
Soroka Medical Center, Yitzhack I. Rager Blvd. 151, Be'er Sheva, Israel.
Purpose: This study aimed to validate the new DormoTech Vlab device's performance, usability, and validity as a sleep test and physiological data recorder. The novel device has been designed for patient comfort, ease of use, and home-based assessment of sleep disordered breathing and other sleep-related measurements.
Methods: Forty-seven adults (mean age = 52 years, 42% female, body mass index 29.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!