A new cobyrinate/protoporphyrin IX molecular hybrids were prepared via CuAAC reaction. The synthesis involved selective preparation of cobyrinate and PpIX derived building blocks possessing respectively terminal alkyne and azide moieties followed by the CuOAc catalyzed cycloaddition reaction. Synthesized molecules activated soluble guanylyl cyclase showing strong linker length/activation dependence.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600653 | PMC |
| http://dx.doi.org/10.1002/ejoc.201201303 | DOI Listing |
Publication Analysis
Top Keywords
soluble guanylyl
8
guanylyl cyclase
8
protoporphyrin ix/cobyrinate
4
ix/cobyrinate derived
4
derived hybrids
4
hybrids novel
4
novel activators
4
activators soluble
4
cyclase cobyrinate/protoporphyrin
4
cobyrinate/protoporphyrin molecular
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!