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Pantoprazole-induced Thrombocytopenia: Unresponsive to Corticosteroid and Thrombocyte Concentrate Transfusion.
J Pharm Pract
June 2023
Master of Clinical Pharmacy Program of University Gadjah Mada, Yogyakarta, Indonesia.
Pantoprazole is a proton pump inhibitor (PPI) class drug that is widely used in the treatment of SRMD (stress-related mucosal disease in critical ill patients. PPI are one class of drugs used commonly both for treatment and prophylactic therapy for stress ulcers in intensive care unit (ICU). We report a case of a 51-year old male who was referred to PKU Hospital.
View Article and Find Full Text PDFPantoprazole-induced thrombocytopenia in patients with upper gastrointestinal bleeding.
Platelets
September 2015
Department of Internal Medicine, Çanakkale Onsekiz Mart University, Çanakkale , Turkey .
Proton pump inhibitors (PPIs) are highly effective drugs for patients suffering from peptic ulcer and gastro-esophageal reflux diseases, but recent studies have indicated possible risks with the long-term use of PPIs, such as osteoporosis, fractures, increased risk of pneumonia, diarrhea, iron and vitamin B12 deficiencies. There are publications written as a case study that indicate thrombocytopenia as side effects of PPIs, but there is no study on this subject. This study aimed to investigate the development of thrombocytopenia in patients with short-term use of PPI-infusion therapy.
View Article and Find Full Text PDFPantoprazole-induced thrombocytopenia.
Ann Pharmacother
April 2006
Department of Pharmacy, College of Pharmacy, University of Oklahoma, Oklahoma City, OK 73117, USA.
Objective: To report 2 cases of thrombocytopenia associated with pantoprazole treatment and discuss existing reports on this drug-induced adverse event.
Case Summaries: This paper describes the course of thrombocytopenia associated with pantoprazole 40 mg in 2 hospitalized patients. In both cases, thrombocytopenia appeared after the initiation of pantoprazole and rapidly improved after discontinuation of pantoprazole, although complete resolution of thrombocytopenia occurred in only one patient prior to discharge from the hospital.
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