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[Double Valves Repair for Mitral and Tricuspid Regurgitation due to Barlow's Disease:Report of a Case].
Kyobu Geka
November 2024
Department of Thoracic and Cardiovascular Surgery, Hirosaki University, Hirosaki, Japan.
A 75-year-old man with mitral regurgitation (MR) and tricuspid regurgitation (TR) caused by Barlow 's disease was referred to our hospital. He had a history of persistent atrial fibrillation. Echocardiography showed severe MR with bi-leaflet billowing and functional TR.
View Article and Find Full Text PDFAn Unexpected Finding in an Adolescent Rowing Athlete With Angina Pectoris. A Case Report.
Clin J Sport Med
November 2024
Heart Center, Hospital da Cruz Vermelha Portuguesa, Lisboa, Portugal; and.
Significant intraventricular gradient development during exercise is rare, usually occurring with left ventricular hypertrophy. The etiopathogenesis consists of the increase in nonobstructive physiological gradients; ventricular cavitary obliteration with consequent end-systolic obstruction; and midsystolic obstruction caused by systolic anterior movement of the mitral valve compromising flow. A correlation between intraventricular gradient development and various symptoms has been established.
View Article and Find Full Text PDFNeuroprotective agents ineffective in mitigating autonomic dysreflexia following experimental spinal cord injury.
Exp Neurol
December 2024
International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada; Department of Medicine, Division of Physical Medicine and Rehabilitation, University of British Columbia, Vancouver, Canada; GF Strong Rehabilitation Centre, Vancouver Coastal Health, Vancouver, Canada. Electronic address:
Article Synopsis
- The study investigates the cardiovascular dysfunction caused by spinal cord injury (SCI) and assesses the efficacy of four neuroprotective agents in aiding cardiovascular recovery.
- Male Wistar rats were given spinal contusions and treated with Fluoxetine, Glyburide, Valproic acid, and Indomethacin, with outcomes measured through blood pressure changes, locomotor function, and lesion area.
- The results showed that Indomethacin and Valproic acid led to high mortality rates, while Fluoxetine and Glyburide were tolerated, but none of the treatments significantly improved blood pressure control or locomotor function compared to the control group.
Rates of Acute Brain Injury Among Severely Hypertensive Patients Seen in the Emergency Department.
Neurohospitalist
October 2024
Clinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Background: Identifying patients with acute brain injury among patients who present to the Emergency Department (ED) with severe hypertension can be challenging. We explored rates of brain injury in a cohort of ED patients with severe hypertension in whom acute target-organ damage was or was not initially suspected.
Methods: We conducted a retrospective chart-review study at two different hospitals within the same urban health system.
A disproportionality analysis of low molecular weight heparin in the overall population and in pregnancy women using the FDA adverse event reporting system (FAERS) database.
Front Pharmacol
August 2024
Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Foshan, Guangdong, China.
Article Synopsis
- The study investigates adverse events (AEs) linked to low molecular weight heparin (LMWH), particularly focusing on its use in the general population and pregnant women, using the FDA Adverse Event Reporting System.
- Various analytical methods were utilized, including reporting odds ratios and Bayesian approaches, to identify significant AE signals associated with LMWH.
- Key findings revealed several notable AEs for both the overall population (e.g., anti factor X antibody positive) and pregnant women (e.g., sternal fracture), highlighting the need for more attention to the adverse effects of LMWH in clinical settings.
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