[Variability of the response of the microvascular bed to medicamental vasodilation in patients with arterial hypertension].

The aim of the work was to estimate changes of microcirculation (MC) in patients with arterial hypertension (AH) with different types of peripheral hemocirculation in response to a single intake of corinfar. The study included 45 patients (mean age 54.3 +/- 1.1 yr) with grade 2-3 AH. MC in the forearm skin was evaluated by laser Doppler flowmetry before and 2 hr after sublingual administration of corinfar (20 mg). The response was found to depend on the initial character of MC. 40% of the patients underwent positive changes characterized by reduced constriction of microvessels, increased capillary bloodflow and its reserve potential, improved venous outflow suggesting productive growth of tissue perfusion. Corinfar caused dyscoordination of MC regulation and reduction of tissue hemoperfusion in each 5th (22.2%) patient. These data suggest different functional reaction of MC to the treatment of AH and its varying organoprotective effect.