AI Article Synopsis
- The study aimed to compare the effectiveness of double-balloon endoscopy (DBE) and FDG-PET in detecting jejunoileal lymphoma in 31 patients with confirmed malignant lymphoma.
- Among 20 patients who underwent both procedures, FDG-PET identified lymphoma in 50% of cases, with notably lower detection rates for follicular lymphoma compared to other lymphoma types.
- The results suggest that DBE is crucial for accurately diagnosing instances of small intestinal lymphoma, particularly follicular lymphoma, which is often missed by FDG-PET.
Article Abstract
Aim: To investigate the feasibility of double-balloon endoscopy (DBE) to detect jejunoileal lymphoma, compared with fluorodeoxyglucose positron emission tomography (FDG-PET).
Methods: Between March 2004 and January 2011, we histologically confirmed involvement of malignant lymphoma of the jejunoileum in 31 patients by DBE and biopsy. In 20 patients of them, we performed with FDG-PET. We retrospectively reviewed the records of these 20 patients. Their median age was 64 years (range 50-81). In the 20 patients, the pathological diagnosis of underlying non-Hodgkin's lymphoma (NHL) comprised follicular lymphoma (FL, n = 12), diffuse large B cell lymphoma (DLBCL, n = 4), mantle cell lymphoma (MCL, n = 2), enteropathy associated T cell lymphoma (ETL, n = 1) and anaplastic large cell lymphoma (ALCL, n = 1).
Results: Ten cases showed accumulation by FDG-PET (50%). FDG-PET was positive in 3 of 12 FL cases (25%) while in 7 of 8 non-FL cases (88%, P < 0.05). Intestinal FL showed a significantly lower rate of positive FDG-PET, in comparison with other types of lymphoma. Cases with endoscopically elevated lesions (n = 10) showed positive FDG-PET in 2 (20%), but those with other type NHL did in 8 of 10 (80%, P < 0.05). When the cases having elevated type was compared with those not having elevated type lesion, the number of cases that showed accumulation of FDG was significantly smaller in the former than in the latter.
Conclusion: In a significant proportion, small intestinal involvement cannot be pointed out by FDG-PET. Especially, FL is difficult to evaluate by FDG-PET but essentially requires DBE.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600546 | PMC |
| http://dx.doi.org/10.4253/wjge.v5.i3.111 | DOI Listing |
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