Objective: To gain insight into the duration and the various components of the clinical treatment course for patients with symptomatic carotid artery stenosis, in order to improve the care provided to these patients.
Design: Retrospective cohort study.
Methods: All patients who had undergone a carotid intervention for significant symptomatic carotid stenosis from 2001 to 2011 were included. Quantile regression analysis was used to assess the changes which had occurred in the median duration of the period from neurological event to intervention from 2001 onward. In order to chart the clinical treatment course, it was split up in different components. In addition, the impact of the referrer and the relationship between the time of the intervention and the risk of perioperative complications were also evaluated.
Results: The median duration of the entire clinical treatment course decreased during the study period from 79 days (interquartile range (IQR): 59-113) in the reference period 2001-2004 to 19 days (IQR: 13-28) in 2011. All components of the clinical pathway had contributed to this decline. The duration of the clinical course in patients who had been externally referred was more than 3 times longer (median 67 vs. 21 days, p < 0.01). The total duration of the process did not affect the number of perioperative complications.
Conclusion: In the last decennium, the duration of the clinical treatment course of care in patients with symptomatic carotid artery disease was greatly reduced. Analyses of the processes which make up the chain of events, however, reveal that there is still much to be gained in the period before initial presentation at the hospital for patients who are referred by their general practitioners as well as those referred by other hospitals.
Download full-text PDF |
Source |
---|
Am J Physiol Heart Circ Physiol
January 2025
Comenius University Bratislava, Faculty of Pharmacy, Department of Pharmacology and Toxicology, Bratislava, Slovakia.
Cholinesterase (ChE) inhibitors are under consideration to be used in the treatment of cardiovascular pathologies. A prerequisite to advancing ChE inhibitors into the clinic is their thorough characterization in the heart. The aim here was to provide a detailed analysis of cardiac ChE to understand their molecular composition, localization, and physiological functions.
View Article and Find Full Text PDFBackground: An estimated 17% of all couples worldwide are involuntarily childless (infertile). The clinically identifiable causes of infertility can be found in the male or female partner or in both. The molecular pathophysiology of infertility still remains unclear in many cases but is increasingly being revealed by genetic analyses.
View Article and Find Full Text PDFHum Vaccin Immunother
December 2025
Research and Development, Infectious Disease, Moderna, Inc., Cambridge, MA, USA.
Safety, immunogenicity, and effectiveness of an mRNA-1273 50-μg booster were evaluated in adolescents (12-17 years), with and without pre-booster SARS-CoV-2 infection. Participants who had received the 2-dose mRNA-1273 100-µg primary series in the TeenCOVE trial (NCT04649151) were offered the mRNA-1273 50-μg booster. Primary objectives included safety and inference of effectiveness by establishing noninferiority of neutralizing antibody (nAb) responses after the booster compared with the nAb post-primary series of mRNA-1273 among young adults in COVE (NCT04470427).
View Article and Find Full Text PDFJ Speech Lang Hear Res
January 2025
Division of Speech Pathology and Audiology, Research Institute of Audiology and Speech Pathology, College of Natural Sciences, Hallym University, Chuncheon, South Korea.
Purpose: Tools that can reliably measure changes in the perception of tinnitus following interventions are lacking. The minimum masking level, defined as the lowest level at which tinnitus is completely masked, is a candidate for quantifying changes in tinnitus perception. In this study, we aimed to determine minimal clinically important differences for minimum masking level.
View Article and Find Full Text PDFBackground: Age-related macular degeneration (AMD), a condition of multifactorial origin, is a major cause of irreversible vision loss in industrialized countries. The dry late stage of the disease, known as geographic atrophy (GA), is characterized by progressive loss of photoreceptor cells and retinal pigment epithelial cells in the central retina. An estimated 300 000 to 550 000 people in Germany suffer from GA.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!