AI Article Synopsis
- There is significant research on T cell recognition of Epstein-Barr virus cells, but less is known about gamma-2 herpesvirus-immortalized B cells.
- This study demonstrates that murine gammaherpesvirus 68 (MHV-68) can be controlled by both CD4 and CD8 T cells in living organisms.
- The findings provide evidence of the direct recognition of infected B cells by these T cells, which could aid in developing treatments for diseases related to gamma-2 herpesviruses.
Article Abstract
There has been extensive research regarding T cell recognition of Epstein-Barr virus-transformed cells; however, less is known regarding the recognition of B cells immortalized by gamma-2 herpesviruses. Here we show that B cells immortalized by murine gammaherpesvirus 68 (MHV-68, γHV-68) can be controlled by either CD4 or CD8 T cells in vivo. We present evidence for the direct recognition of infected B cells by CD4 and CD8 T cells. These data will help in the development of immunotherapeutic approaches combating gamma-2 herpesvirus-related disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648166 | PMC |
| http://dx.doi.org/10.1128/JVI.00375-13 | DOI Listing |
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