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We investigate the ultrafast electron correlation effects during non-sequential double ionization (NSDI) of argon subjected to a combined femtosecond field composed of counter-rotating two-color circularly polarized (TCCP) pulse laser using a 3D classical ensemble model (CEM). Our simulation results reveal that manipulation of the carrier-envelope phase (CEP) of the external driving field modulates the dynamical behavior of the two electrons, resulting in a notable sensitivity of their momentum distribution to the relative phase of two components of the counter-rotating TCCP field. Through inversion analysis, we uncover the capability to direct electrons toward a single direction, thereby facilitating focused ion-electron collisions on the attosecond timescale.
View Article and Find Full Text PDFModulating Enzyme's Conformational Space: Impact of Substrate Binding, Mode Alteration, and Active Site Mutation in DapC, an Aminotransferase Enzyme of Lysine Biosynthetic Pathway.
J Phys Chem B
January 2025
Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
The microbial aminotransferase enzyme DapC is vital for lysine biosynthesis in various Gram-positive bacteria, including . Characterization of the enzyme's conformational dynamics and identifying the key residues for ligand binding are crucial for the development of effective antimicrobials. This study employs atomistic simulations to explore and categorize the dynamics of DapC in comparison to other classes of aminotransferase.
View Article and Find Full Text PDFAdvancing osseointegration research: A dynamic three-dimensional (3D) culture model for dental implants.
J Dent Sci
January 2025
Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, Los Angeles, CA, USA.
Background/purpose: studies are essential for understanding cellular responses, but traditional culture systems often neglect the three-dimensional (3D) structure of real implants, leading to limitations in cellular recruitment and behavior largely governed by gravity. The objective of this study was to pioneer a novel 3D dynamic osteoblastic culture system for assessing the biological capabilities of dental implants in a more clinically and physiologically relevant manner.
Materials And Methods: Rat bone marrow-derived osteoblasts were cultured in a 24-well dish with a vertically positioned dental implant.
Model-based perfusion reconstruction with time separation technique in cone-beam CT dynamic liver perfusion imaging.
Med Phys
January 2025
Institute for Medical Engineering, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Background: The success of embolization, a minimally invasive treatment of liver cancer, could be evaluated in the operational room with cone-beam CT by acquiring a dynamic perfusion scan to inspect the contrast agent flow.
Purpose: The reconstruction algorithm must address the issues of low temporal sampling and higher noise levels inherent in cone-beam CT systems, compared to conventional CT.
Methods: Therefore, a model-based perfusion reconstruction based on the time separation technique (TST) was applied.
Nuclear Magnetic Resonance Study of Monoclonal Antibodies Near an Oil-Water Interface.
J Pharm Sci
January 2025
Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, USA, 32310; Center for Interdisciplinary Magnetic Resonance, National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, USA, 32310. Electronic address:
Monoclonal antibodies (mAb) represent an important class of biologic therapeutics that can treat a variety of diseases including cancer, autoimmune disorders or respiratory conditions (e.g. COVID-19).
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