Anti-cytokine therapies in T1D: Concepts and strategies.

Clin Immunol

Benaroya Research Institute, 1201 Ninth Av, Seattle, WA 98101 USA. Electronic address:

Published: December 2013

Therapeutic targeting of proinflammatory cytokines is clinically beneficial in several autoimmune disorders. Several of these cytokines are directly implicated in the pathogenesis of type 1 diabetes, suggesting opportunities for design of clinical trials in type 1 diabetes that incorporate selective cytokine blockade as a component of preventative or interventional immunotherapy. The rationale and status of inhibitory therapy directed against IL-1, TNF, IL-12, IL-23, and IL-6 are discussed, towards a goal of using cytokine inhibition as a therapeutic platform to establish an in vivo milieu suitable for modulating the immune response in T1D.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700624PMC
http://dx.doi.org/10.1016/j.clim.2013.02.003DOI Listing

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