Early determination in the C. elegans embryo: a gene, cib-1, required to specify a set of stem-cell-like blastomeres.

Development

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

Published: January 1990

The early somatic blastomeres founding the tissues in the C. elegans embryo are derived in a stem-cell-like lineage from the P cells. We have isolated maternal effect lethal mutations defining the gene cib-1 in which the P cells, P1-P3, skip a cell cycle and acquire the fates of only their somatic daughters. Therefore, the cib-1 gene is required for the specification of the stem-cell-like fate of these cells. The analysis of the development of these mutants suggests that the clock controlling the cell cycles in the early embryo is directly coupled to the fate of a cell and that there must be another developmental clock that activates the determinative inventory for the early decision-making.

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.108.Supplement.107DOI Listing

Publication Analysis

Top Keywords

elegans embryo
8
gene cib-1
8
early
4
early determination
4
determination elegans
4
embryo gene
4
cib-1 required
4
required set
4
set stem-cell-like
4
stem-cell-like blastomeres
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!