AI Article Synopsis
- The study aimed to investigate the interactions between ethanol extracts of two plants, Amburana cearensis and Anadenanthera macrocarpa, and six antimicrobial drugs against resistant strains of Staphylococcus aureus and Escherichia coli.
- The antibacterial effectiveness was measured using the minimum inhibitory concentration (MIC) method, and a microdilution assay was conducted to explore interactions between the natural extracts and antibiotics.
- Notably, the combination of amikacin with Anadenanthera macrocarpa extract significantly improved its effectiveness against one E. coli strain, while β-lactam antibiotics generally did not show enhanced activity, and some interactions, like with ampicillin, were antagonistic.
Article Abstract
The aim of this study was to verify the possible interactions between ethanol extracts of Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan, combined with six antimicrobial drugs against multiresistant strains of Staphylococcus aureus and Escherichia coli isolated from humans. The antibacterial activity of the extracts was determined using the minimum inhibitory concentration (MIC). The microdilution assay was performed to verify the interactions between the natural products and the antibiotics using a subinhibitory concentration. The activity of amikacin associated with the extract of Anadenanthera macrocarpa against EC 27 was enhanced, demonstrating an MIC reduction from 128 to 4 μg/mL. Among the β-lactams, no potentiation on its activity was observed, with exception to the antagonism of the natural products with ampicillin against S. aureus 358.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591201 | PMC |
| http://dx.doi.org/10.1155/2013/640682 | DOI Listing |
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