AI Article Synopsis
- Optical frequency domain imaging (OFDI) offers detailed imaging of the esophagus with a resolution of ~7 μm, enhancing the ability to differentiate between squamous mucosa, gastric cardia mucosa, and Barrett's esophagus (BE).
- A study aimed to assess the consistency among various OFDI readers in identifying these tissue types, utilizing validated OCT criteria, with a focus on inter- and intra-observer agreement.
- Results showed high agreement among readers in distinguishing between BE and non-BE mucosa, indicating that trained readers can reliably differentiate these tissue types using OFDI technology.
Article Abstract
Background: Optical frequency domain imaging (OFDI) is a second-generation form of optical coherence tomography (OCT) providing comprehensive cross-sectional views of the distal esophagus at a resolution of ~7 μm.
Aim: Using validated OCT criteria for squamous mucosa, gastric cardia mucosa, and Barrett's esophagus (BE), the objective of this study was to determine the inter- and intra-observer agreements by a large number of OFDI readers for differentiating these tissues.
Methods: OFDI images were obtained from nine subjects undergoing screening and surveillance for BE. Sixty-four OFDI image regions of interest were randomly selected for review. A training set of 19 images was compiled distinguishing squamous mucosa from gastric cardia and BE using previously validated OCT criteria. The ten readers then interpreted images in a test set of 45 different images of squamous mucosa (n = 15), gastric cardia (n = 15), or BE (n = 15). Interobserver agreement differentiating the three tissue types and BE versus non-BE mucosa was determined using multi-rater Fleiss's κ value. The images were later randomized again and four readers repeated the test 3 weeks later to assess intraobserver reliability.
Results: All ten readers showed excellent agreement for the differentiation of BE versus non-BE mucosa (κ = 0.811 p < 0.0001) and for differentiating BE versus gastric cardia versus squamous mucosa (κ = 0.866, p < 0.0001). For the four readers who repeated the test, the median intraobserver agreement (BE vs. non-BE) was high (κ = 0.975, IQR: 0.94, 1.0).
Conclusions: Trained readers have a high interobserver agreement for differentiating BE, squamous, and gastric cardia mucosa using OFDI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732518 | PMC |
| http://dx.doi.org/10.1007/s10620-013-2625-x | DOI Listing |
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