We demonstrate the on-chip preparation of size-controllable supramolecular gelatin nanoparticles (SGNs) with a quantum dot (QD) payload as matrix metalloproteinase (MMP) responsive cancer cell imaging probes.
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Deferoxamine-loaded gelatin methacryloyl hydrogel endue 3D-printed PGCL-hydroxyapatite scaffold with angiogenesis, anti-oxidative and immunoregulatory capacities for facilitating bone healing.
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Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China. Electronic address:
Promoting angiogenesis, alleviating oxidative stress injury and inflammation response are crucial for bone healing. Herein, the deferoxamine (DFO)-loaded gelatin methacryloyl (GelMA) hydrogel coating (GelMA-DFO) was constructed on the 3D-printed poly(Glycolide-Co-Caprolactone)-hydroxyapatite (PGCL-HAP) scaffold. After the hydrogel coating was established, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscope (SEM) and water contact angle measurement were employed to evaluate the characteristic and the biological properties were assessed.
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View Article and Find Full Text PDFA Novel Dual Cross-linking Reagent for Dentin Bonding Interface Stability.
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Article Synopsis
- Injuries like cartilage defects contribute significantly to joint diseases and can speed up arthritis development by disrupting the articular surface.
- The study introduces a dual-network hydrogel called GelMA-FT/Sr, which features enhanced lubrication and supports cartilage healing due to its composition, including GelMA, an FT network, and strontium ions.
- Results show that this hydrogel not only lubricates well but also promotes the differentiation of stem cells into cartilage, demonstrating effectiveness in repairing cartilage defects in a rat model, making it a promising tool for tissue engineering.
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