AI Article Synopsis
- Langerhans cell histiocytosis (LCH) is a rare condition characterized by the abnormal proliferation of Langerhans cells, often seen as a bone lesion, especially in children.
- A case study of a 2-year-old boy demonstrated symptoms like fever, bleeding gums, and a rash, along with severe bone loss around his teeth, prompting a gingival biopsy.
- Although the exact cause of LCH is unknown, it may be linked to environmental factors and viruses like Epstein-Barr, and oral symptoms might be the first signs of the disease.
Article Abstract
Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of histiocytes characterised by a proliferation of abnormal and clonal Langerhans cells. LCH most commonly occurs as a localised solitary bone lesion and appears predominantly in paediatric patients. This case report presents clinicopathological features of this disorder in a 2-year-old boy. The presenting features of the patient included fever, bleeding gums and seborrheic dermatitis-like rash. Intraoral examination and radiographs revealed deep pockets and severe bone loss around all primary molars. Due to severe periodontal destruction, a gingival biopsy was taken. The biopsy specimen revealed heavy infiltration of Langerhans histiocytes. Chemotherapy was administered. Although no clear cause of LCH has been identified, the disease can be triggered by environmental agents and viruses, in particular Epstein-Barr virus. Oral manifestations may be the first or only signs of LCH.
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