AI Article Synopsis
- Carvedilol is a multi-action drug that blocks various adrenoceptors and has strong antioxidant effects, making it effective for treating congestive heart failure.
- Despite initial skepticism and regulatory challenges during its development in the early 1990s, it was proven in a large clinical study to significantly reduce illness and death rates for heart failure patients.
- The journey of carvedilol's approval offers valuable insights for scientists, regulators, and healthcare professionals about overcoming obstacles in medical advancements.
Article Abstract
Carvedilol is a multiple action drug that blocks β1-, β2- and α1- adrenoceptors, and has potent antioxidant properties. Carvedilol is the first drug of its kind to be approved for the treatment of congestive heart failure, and is now the standard of care for this devastating disease. The discovery and development of carvedilol encountered an adverse regulatory climate, skepticism by the cardiology community and hesitance by the company, and in the early 1990s, the fate of the drug was uncertain. Nonetheless, in the largest heart failure study conducted up until that point, carvedilol produced marked reductions in morbidity and mortality, and has given new hope to patients afflicted with congestive heart failure. The story behind carvedilol contains important observations and lessons for scientists, regulators and physicians.
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| http://dx.doi.org/10.1517/17460441.1.1.85 | DOI Listing |
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