A clinically healthy 16-yr-old female leopard (Panthera pardus orientalis) was diagnosed with a patent ductus arteriosus on echocardiography and later confirmed on necropsy A murmur was heard on auscultation during a routine examination, and the congenital defect was an incidental finding. The animal had been asymptomatic its entire life. This deformity is rarely observed in nondomestic felids and may be asymptomatic, as has been described in domestic cats.
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http://dx.doi.org/10.1638/1042-7260-44.1.200 | DOI Listing |
Ann Thorac Surg Short Rep
September 2023
Department of Surgery, Duke University Medical Center, Durham, North Carolina.
Congenital Gerbode defects, consisting of a deficiency in the membranous septum causing left ventricle-to-right atrium shunting, are rarely hemodynamically significant. Here, we present the case of a neonate with a large unrestrictive Gerbode defect, patent foramen ovale, patent ductus arteriosus, and pulmonary valve insufficiency resulting in a circular intracardiac shunt and cardiogenic shock. The patient was managed with venoarterial extracorporeal membrane oxygenation followed by neonatal Gerbode defect repair.
View Article and Find Full Text PDFAm J Perinatol
January 2025
Pediatrics, University of California San Francisco, San Francisco, United States.
Objective: Extremely premature infants are treated with acetaminophen (APAP) for pain and patent ductus arteriosus. High doses of APAP in adults are toxic, and a recent study found an association between APAP metabolite levels in mothers' breast milk and both bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) in their premature infants. In this study, we determined levels of APAP metabolites in urine of infants at high risk for BPD and ROP.
View Article and Find Full Text PDFCureus
December 2024
Pediatrics, Alessandrescu-Rusescu National Institute of Mother and Child Health, Bucharest, ROU.
Introduction: Congenital heart disease (CHD) is diagnosed with high prevalence. Pulse oximetry and clinical examination are screening tools to aid in obtaining a CHD diagnosis.
Materials And Methods: We conducted a retrospective longitudinal study over three years, screening 1188 newborns admitted to the neonatal intensive care unit (NICU) during the first 72 hours of life.
Clin Case Rep
January 2025
Department of Radiology and Radiotherapy, School of Medicine, College of Health Sciences Makerere University Kampala Uganda.
Double outlet right ventricle (DORV) is a rare congenital heart defect where both the aorta and pulmonary artery originate from the right ventricle, often accompanied by additional cardiac anomalies to mitigate circulatory imbalance, though such compensations usually fail. We report a 15-month-old infant with recurrent respiratory infections and poor weight gain, referred for computed tomography angiography. Physical examination showed a small, non-syndromic infant with pallor, tachypnea, irritability, and finger clubbing.
View Article and Find Full Text PDFPharmaceuticals (Basel)
November 2024
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Clinical Pharmacology and Toxicology, Embryotox Center of Clinical Teratology and Drug Safety in Pregnancy, Augustenburger Platz 1, 13353 Berlin, Germany.
Paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used during pregnancy. Due to their fetotoxicity, NSAIDs are contraindicated during the third trimester. There is ongoing controversy about the extent to which NSAIDs may cause cardiovascular and renal impairment in the fetus earlier in the second trimester.
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