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Defining trimester-specific reference intervals for carbohydrate deficient transferrin in pregnant women.
Clin Chim Acta
February 2024
Department of Clinical Chemistry and Hematology, Meander Medical Centre, Amersfoort, the Netherlands.
Objectives: Extensive consumption of alcohol during pregnancy can lead to severe complications for the unborn child. Carbohydrate-deficient transferrin (CDT) levels in serum have become a common biomarker for excessive alcohol intake. However, during pregnancy CDT levels can rise to levels above commonly used cut-off values, for reasons unrelated to alcohol intake.
View Article and Find Full Text PDFAccuracy of carbohydrate-deficient transferrin as a biomarker of chronic alcohol abuse during treatment for alcoholism.
Hepatol Res
January 2022
Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan.
Aim: Clinical evaluations are generally used to verify the effectiveness of detoxification treatments for alcohol dependence, but new objective biomarkers are essential for accurate diagnosis. We aim to assess the accuracy of carbohydrate-deficient transferrin (%CDT) in a cohort of Japanese patients admitted to a psychiatric hospital specializing in alcohol dependence. In addition, we investigated the kinetics of %CDT during alcohol moderation or cessation.
View Article and Find Full Text PDFEvaluation of carbohydrate-deficient transferrin measurements on the V8 capillary electrophoresis system and comparison with the IFCC approved HPLC reference method and N-Latex immunonephelometric assay.
Clin Chem Lab Med
February 2021
Department of Clinical Chemistry and Hematology, Meander Medical Centre, Amersfoort, The Netherlands.
Objectives: Carbohydrate-deficient transferrin (CDT) measurements are commonly used for the identification and follow-up of individuals suspected of chronic alcohol abuse. This study describes the analytical characteristics of the CDT assay on the Helena Biosciences V8 electrophoresis analyzer and compares its diagnostic performance to the International Federation of Clinical Chemistry and Laboratory Medicine approved high performance liquid chromatography (HPLC) method and the N-Latex CDT immunonephelometric assay.
Methods: The analytical performance of the V8 assay, including the linearity and the imprecision, was studied at two separate locations.
Independence of carbohydrate-deficient isoforms of transferrin and cyclic citrullinated peptides in rheumatoid arthritis.
Rev Bras Reumatol Engl Ed
September 2019
Medical University of Białystok, Department of Biochemical Diagnostics, Białystok, Poland. Electronic address:
Objective: The aim of this study was to assess the relationship between the two types of posttranslational modifications of proteins in RA: glycosylation on the example of carbohydrate-deficient transferrin and citrullination by means of autoantibodies to cyclic citrullinated peptides.
Methods: The study was carried out in 50 RA patients. CDT was measured using N Latex CDT immunonephelometric test, the results were presented in absolute and relative units.
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