Although chemical mechanisms for the formation of nitrosothiol from •NO have been studied extensively "in the test tube", surprisingly little is known regarding the mechanism(s) of how nitrosothiols are formed . This lack of understanding has hampered more general acceptance of the concept of cysteine nitrosothiol formation as a generally applicable, regulated, and functionally significant protein posttranslational modification (as opposed to multiple other •NO-induced thiol modifications). Here we provide a brief overview/summary of the cellular formation of nitrosothiols from •NO two possible mechanisms involving oxygen or transition metals.
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