One-pot tandem cyclization of enantiopure asymmetric cis-2,5-disubstituted pyrrolidines: Facile access to chiral 10-heteroazatriquinanes.

Beilstein J Org Chem

Department of Medicinal Chemistry, School of Pharmacy, The Fourth Military Medical University, Changle Xilu 17, Xi-An, 710032, P. R. China.

Published: March 2013

A series of chiral 10-heteroazatriquinanes were synthesized from enantiopure asymmetric cis-2,5-disubstituted pyrrolidines through a one-pot tandem cyclization procedure. The structures and configurations of these new chiral 10-heteroazatriquinanes are confirmed by X-ray single-crystal diffraction analysis.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596118PMC
http://dx.doi.org/10.3762/bjoc.9.32DOI Listing

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