Background: We aimed to assess whether echocardiographically-optimised atrioventricular (AV) and interventricular (VV) delay programming provided any additional benefit over standard settings following biventricular pacemaker implantation in patients with advanced heart failure.
Methods: Paired data were collected on 22 patients (aged 67.5 ± 8.3 years, 16 male) with refractory heart failure, NYHA class III/IV symptoms, sinus rhythm, LBBB and a broad QRS complex >120 ms. All patients underwent implantation of a biventricular pacemaker and were randomised to eight weeks of factory pacing mode (Mode 1) or echocardiographically-guided pacing mode (Mode 2), followed by eight weeks in the alternate mode, in a randomised blinded crossover design.
Results: Peak oxygen consumption, 6 min walk distance, NYHA class and quality of life scores improved after biventricular pacing, but no significant difference was found between the two modes, with the exception of peak oxygen consumption score (baseline: 14.8 ± 0.9, Mode 1: 14.6 ± 1.2, Mode 2: 16.1 ± 1.2 mL/kg/min), which was better in Mode 2 than Mode 1 (p 0.003).
Conclusion: Transthoracic echocardiographic optimisation of AV and VV delays following biventricular pacing may offer additional clinical benefit in an unselected group of patients when compared with factory settings.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.hlc.2013.01.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cu-Mn Nanocomposite for Enhanced Tumor Cuproptosis achieved by Remodeling the Tumor Microenvironment and Activating the Antitumor Immunogenic Responses.
Acta Biomater
January 2025
College of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China. Electronic address:
Cuproptosis is a newly discovered mode of cell death, which is caused by excess copper and results in cell death via the mitochondrial pathway. However, the complex tumor microenvironment (TME) is characterized by many factors, including high levels of glutathione and lack O, limit the application of traditional cuproptosis agents in antitumor therapy. Herein, we report a hyaluronic acid modified copper-manganese composite nanomedicine (CMCNs@HA) to remodel the TME and facilitate efficient cuproptosis in tumor.
View Article and Find Full Text PDFHow Effective is Low-dose Radiotherapy (LD-RT) for Heberden's Osteoarthritis? An Analysis of the Current Literature.
Z Orthop Unfall
January 2025
Geschäftsstelle Mannheim, Deutsche Arthrose-Hilfe e.V., Mannheim, Deutschland.
Low-dose radiotherapy is an established treatment option for non-malignant skeletal disorders. It is used in the treatment of Heberden's osteoarthritis (HA), but the evidence of efficacy does not seem to be certain. This paper reviews current literature for scientific evidence of efficacy in the treatment of HA.
View Article and Find Full Text PDFBackground-free luminescent and chromatic assay for strong visual detection of creatinine.
Talanta
January 2025
Key Laboratory of Photovoltaic and Energy Conservation Materials, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China. Electronic address:
Creatinine is an essential biomarker for the clinical diagnosis and treatment of renal insufficiency. Although fluorescent methods are powerful tools for creatinine detection, almost all reported fluorescent probes rely on short-wavelength excitation and a single fluorescent signal, making them susceptible to environmental and operational conditions. In this study, a near-infrared excited, highly sensitive, and multi-output signal sensing system was established using upconversion nanoparticles and 3,5-dinitrobenzoic acid (DNBA) for synergistic luminescent and colorimetric assay for strong visual detection of creatinine.
View Article and Find Full Text PDFA photodetector for red and green with balanced negative and positive photocurrent for imaging is realized.
Sci Rep
January 2025
Guangdong Provincial Key Laboratory of Optical Information Materials and Technology, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou, 510006, People's Republic of China.
A dual-polarity, photovoltaic photodetector for red-green dual-wavelength detection is demonstrated, operating in the self-powered mode. It is based on a core-shell n-InGaN nanowire/p-CuO heterostructure with inner upward energy band bending and near surface downward energy band bending. This produces negative photocurrent for red light illumination and positive photocurrent for green light illumination.
View Article and Find Full Text PDFTilting deformation analysis and instability prediction of arch-locked-segment landslides induced by rainfall.
Sci Rep
January 2025
College of Geosciences and Engineering, North China University of Water Resources and Electric Power, Zhengzhou, 450046, China.
The failure of locked-segment landslides is associated with the destruction of locked segments that exhibit an energy accumulation effect. Thus, understanding their failure mode and instability mechanism for landslide hazard prevention and control is critical. In this paper, multiple instruments, such as tilt sensors, pore water pressure gauges, moisture sensors, matrix suction sensors, resistance strain gauges, miniature earth pressure sensors, a three-dimensional (3D) laser scanner, and a camera, were used to conduct the physical model tests on the rainfall-induced arch locked-segment landslide to analyze the resulting tilting deformation and evolution mechanism.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!