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Comment on "UV Absorption Spectroscopy of the Conformer-Dependent Reactivity of the Four Carbon Criegee Intermediate of Methyl Vinyl Ketone Oxide: An Ab initio Quantum Dynamics Study".
J Phys Chem A
February 2024
Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 106319, Taiwan.
Response to Comment on "Dying in the Sun: Direct evidence for elevated UV-B radiation at the end-Permian mass extinction".
Sci Adv
August 2023
Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, Nanjing 210008, China.
Seddon and Zimmermann have raised questions about the evidence for increased UV-B flux across the end-Permian mass extinction (EPME) that was presented in our recent study, specifically regarding the measurement of UV-B-absorbing compound (UAC) levels in fossil pollen. We respond to these points, arguing that the comparison of FTIR spectra of >250 million-year-old Permian fossil pollen with ~700-year-old subfossil pollen is not valid and that negligible nonrandom interference derived from water vapor fluctuations during data generation cannot coincidentally produce a substantial UAC peak during the EPME. Furthermore, we refute the suggestion that the measured aromatic peak at 1600 cm could have been influenced by diagenetic products from other organic constituents of pollen.
View Article and Find Full Text PDF[Intermittent catheterization: What are the environmental impacts and how can they be reduced?].
Prog Urol
September 2023
GRC 01, GREEN Groupe de recherche clinique en neuro-urologie, AP-HP, hôpital Tenon, Sorbonne Université, 75020 Paris, France.
Introduction: If the use of intermittent catheterization has revolutionized the prognosis of neuro-urology patients, it seems necessary to question the ecological cost of single-use catheters, in a process of decarbonization of the health sector. The aim of this work is to identify the environmental impact of intermittent catheterization and potential solutions to reduce it.
Methods: A review of the literature on the environmental impact of intermittent catheterizations was conducted.
Proteasome inhibitors: The next generation of antimalarial drugs?
Cell Chem Biol
May 2023
Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:
Among promising targets for new antimalarials is the Plasmodium falciparum proteasome. Multiple inhibitors have demonstrated potent antimalarial activity and synergy with artemisinins. Potent irreversible peptide vinyl sulfones offer synergy, minimal resistance selection, and lack of cross-resistance.
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