A 46-year-old woman underwent a Belsey Mark IV antireflux procedure 2 months before admission to the intensive care unit. She had recurrent episodes of major gastrointestinal hemorrhage before the diagnosis of an aortoesophageal fistula was made by computed tomographic scan. A successful urgent endovascular repair was performed in combination with prolonged antibiotic treatment. The patient recovered well after a hospital stay of 3 months, and is still in clinical follow-up at our hospital >2 years after diagnosis.
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Strengthening families to support children affected by HIV and AIDS.
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Child, Youth, Family and Social Development Programme, Human Sciences Research Council, South Africa.
This paper provides an overview of the arguments for the central role of families, defined very broadly, and we emphasise the importance of efforts to strengthen families to support children affected by HIV and AIDS. We draw on work conducted in the Joint Learning Initiative on Children and AIDS's Learning Group 1: Strengthening Families, as well as published data and empirical literature to provide the rationale for family strengthening. We close with the following recommendations for strengthening families to ameliorate the effects of HIV and AIDS on children.
View Article and Find Full Text PDFGlobal publications on the international AIDS epidemic report on the existence of an ever-increasing number of orphans and vulnerable children. It has been suggested that by the end of this decade there will be in excess of 25 million AIDS orphans globally, an issue which will require understanding and organisation of long-term medical, psychological and social support. This study provides a systematic review to examine the use, overuse and misuse of the term orphan and explores the benefits and limitations of this approach.
View Article and Find Full Text PDFInhibition of ERK and JNK decreases both osmosensitive taurine release and cell proliferation in glioma cells.
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Department of Pharmacology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK.
Cell swelling is associated with the activation of an increase in the osmosensitive taurine release (OTR) rate, which serves to decrease cell volume as part of a process known as regulatory volume decrease. OTR, which is sensitive to many pharmacological agents including anion channel blockers and signalling pathway modulators, has also been suggested to play a role in cell cycle progression. At non-cytotoxic concentrations, the anion channel blocker NPPB (25 microM), the extra-cellular signal-regulated kinase inhibitor PD98059 (50 microM), and the c-Jun NH2-terminal kinase inhibitor SP 600125 (5 microM) each decreased the OTR rate by > or =50%, decreased cell proliferation, and increased G0/G1 cell cycle arrest.
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