AI Article Synopsis
- Tissue engineering is a novel approach for bone regeneration that involves using osteogenic cells and various scaffolding materials, aiming to evaluate in vitro and in vivo osteoblast mineralization with mesenchymal stem cells (MSCs) and different carriers like titanium and collagen.
- A Medline search was conducted using various terms related to MSCs and bone regeneration, leading to the inclusion of only two studies out of 80 that presented relevant numerical data.
- Results indicated that β-tricalcium phosphate showed high alkaline phosphatase activity while calcium-deficient hydroxyapatite had elevated osteocalcin expression when combined with MSCs, but no studies were found using titanium as a carrier for these purposes.
Article Abstract
Purpose: Tissue engineering is a new way to regenerate bone tissue, where osteogenic capable cells combine with an appropriate scaffolding material. Our aim was in a Medline Search to evaluate osteoblast mineralization in vitro and in vivo including gene expressing combining mesenchymal stem cells (MSCs) and five different carriers, titanium, collagen, calcium carbonate, calcium phosphate and polylactic acid-polyglycolic acid copolymer for purpose of a meta-or a descriptive analysis.
Materials And Methods: The search included the following MeSH words in different combinations-mesenchymal stem cells, alkaline phosphatase, bone regeneration, tissue engineering, drug carriers, tissue scaffolds, titanium, collagen, calcium carbonate, calcium phosphates and polylactic acid-polyglycolic acid copolymer.
Results: Two out of 80 articles included numerical values and as control, carriers and cells, on mineralization and gene expression. β-tricalcium phosphate (β-TCP) revealed elevated alkaline phosphatase activity, and calcium-deficient hydroxyapatite a greater gene expression of osteocalcin when seeded with induced MSCs.
Conclusion: No data are published on titanium used as a carrier in MSC osteoblast mineralization. A meta- as well as a descriptive analysis includes numerical values of test materials and of control reactions from carrier and cells, respectively. Only two articles fulfilled these requirements.
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| http://dx.doi.org/10.1016/j.jcms.2013.01.047 | DOI Listing |
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