AI Article Synopsis
- A study was conducted to compare spot-scanning proton therapy (SSPT) and intensity-modulated radiation therapy (IMRT) for treating hepatocellular carcinoma (HCC) and evaluate how tumor size affects the risk of radiation-induced liver disease (RILD).
- Ten patients were analyzed with varying tumor sizes, and both treatment methods were extensively planned and assessed for their impact on RILD risk using a specific model.
- Results showed that IMRT significantly increases the RILD risk when the tumor diameter exceeds 6.3 cm, while SSPT maintains a much lower risk, making it a safer option for larger tumors.
Article Abstract
Background: We performed a dosimetric comparison of spot-scanning proton therapy (SSPT) and intensity-modulated radiation therapy (IMRT) for hepatocellular carcinoma (HCC) to investigate the impact of tumor size on the risk of radiation induced liver disease (RILD).
Methods: A number of alternative plans were generated for 10 patients with HCC. The gross tumor volumes (GTV) varied from 20.1 to 2194.5 cm3. Assuming all GTVs were spherical, the nominal diameter was calculated and ranged from 3.4 to 16.1 cm. The prescription dose was 60 Gy for IMRT or 60 cobalt Gy-equivalents for SSPT with 95% planning target volume (PTV) coverage. Using IMRT and SSPT techniques, extensive comparative planning was conducted. All plans were evaluated by the risk of RILD estimated using the Lyman-normal-tissue complication probability model.
Results: For IMRT the risk of RILD increased drastically between 6.3-7.8 cm nominal diameter of GTV. When the nominal diameter of GTV was more than 6.3 cm, the average risk of RILD was 94.5% for IMRT and 6.2% for SSPT.
Conclusions: Regarding the risk of RILD, HCC can be more safely treated with SSPT, especially if its nominal diameter is more than 6.3 cm.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606425 | PMC |
| http://dx.doi.org/10.1186/1748-717X-8-48 | DOI Listing |
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