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Blastoid Variant of Mantle Cell Lymphoma with Extranodal Presentation and Aberrant CD10 Expression.
Int J Appl Basic Med Res
February 2024
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Mantle cell lymphoma (MCL) constitutes 3%-10% of non-Hodgkin lymphoma and is characterized by (11:14)(q13;q32). The common presentation is generalized lymphadenopathy with weight loss, infrequently night sweats, and fever. Among histological subtypes of MCL, the blastoid variant of MCL constitutes 10%-15% of all the cases.
View Article and Find Full Text PDFCooccurrence of CD10-Positive and CD10-Negative Mantle Cell Lymphoma Complicated With Central Nervous System Involvement Solely by CD10-Positive Population.
Cureus
January 2022
Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, JPN.
The neoplastic cells of mantle cell lymphoma (MCL) usually express CD5 and not CD10. However, cases of MCL with aberrant expression of CD10 have been seldom reported. A 71-year-old man presented multiple lymphadenopathies with a bulky tumor of the abdomen.
View Article and Find Full Text PDFScreening Strategy for Detecting Double-Hit Lymphoma in a Resource-Limited Setting.
Appl Immunohistochem Mol Morphol
January 2022
Departments of Histopathology.
Article Synopsis
- The study focuses on identifying aggressive double-hit lymphomas (DHL) in high-grade B-cell non-Hodgkin lymphoma using a combination of histological and immunohistochemical methods, making fluorescent in-situ hybridization (FISH) testing more manageable in low-resource settings.
- Out of 109 analyzed cases, 44% showed BCL2 expression, while MYC co-expression was observed in 30%, with some cases demonstrating double-hit status indicating a more aggressive lymphoma.
- The research concluded that specific characteristics like BCLU/blastoid morphology and MYC/BCL2 co-expression can help accurately select cases for FISH testing, with a 100% sensitivity in identifying DHL using this stratification approach.
CD10-positive mantle cell lymphoma: clinicopathologic and prognostic study of 30 cases.
Oncotarget
February 2018
Department of Hematopathology, UT MD Anderson Cancer Center, Houston, TX, USA.
Mantle cell lymphoma is usually negative for CD10 which is useful in distinguishing MCL from other CD10 + B cell lymphomas. Here we assessed the clinicopathologic features of 30 cases of CD10+ MCL, the largest series to date in the English literature, and compared them with a group of 212 typical MCL cases (CD5+, CD10-negative, CD23-negative, cyclin D1+). The 30 patients with CD10+ MCL included 17 men and 13 women with a median age of 68 years.
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