Male rats of the Wistar strain were exposed at the age of 9, 14 and 18 days for a period of 30 minutes to hypobaric hypoxia corresponding to an altitude of 9,000 m. Twenty-four hours after exposure the right sensoric motor area of the cerebral cortex was repeatedly stimulated (rectangular pulses, 8 Hz, 20 s). Contrary to controls, the 10-day-old animals responded to this stimulation by an epileptic self-sustained after-discharge. In older animals the fits were shorter than in controls. Prolongation of the fits in conjunction with repeated stimulation was preserved. Contrary to controls, after the fourth stimulation the lengthening does not occur. In conjunction with older findings after chronic hypoxia, the authors discuss the possible affection of the monoaminergic mediator system.
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