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| http://dx.doi.org/10.1161/CIRCRESAHA.113.300947 | DOI Listing |
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OPN-Mediated Crosstalk Between Hepatocyte E4BP4 and Hepatic Stellate Cells Promotes MASH-Associated Liver Fibrosis.
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Department of Molecular & Integrative Physiology, University of Michigan Medical School, NCRC 20-3843, 2800 Plymouth Road, Ann Arbor, MI, 48105, USA.
Stressed hepatocytes promote liver fibrosis through communications with hepatic stellate cells (HSCs) during chronic liver injury. However, intra-hepatocyte players that facilitate such cell-to-cell communications are largely undefined. It is previously reported that hepatocyte E4BP4 is potently induced by ER stress and hepatocyte deletion of E4bp4 protects mice from high-fat diet-induced liver steatosis.
View Article and Find Full Text PDFRefining habitat selection for sulfate-reducing bacteria: Evaluating suitability and adaptability for sulfate-metal wastewater treatment during anaerobic-to-aerobic transitions.
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School of Minerals Processing and Bioengineering, Central South University, Changsha, 410083, Hunan, China. Electronic address:
Inoculating sulfate-reducing bacteria (SRB) habitats offers an eco-friendly method for treating sulfate-metal laden wastewater, characterized by high sulfate levels, low pH, and elevated heavy metals. This study optimizes source habitat selection of SRB by evaluating groundwater, sewage sludge, and lake sediment, focusing on their suitability and adaptability to aerobic-anaerobic transitions in industrial settings. Sewage sludge, with its slightly acidic pH, reducing environment, and high nutrient levels (Total organic carbon: 207.
View Article and Find Full Text PDFDecoding the epitranscriptome: a new frontier for cancer therapy and drug resistance.
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Department of Pharmacology, School of Pharmacy, Laboratory of Molecular Pharmacology, Southwest Medical University, Luzhou, Sichuan, 646000, China.
As the role of RNA modification in gene expression regulation and human diseases, the "epitranscriptome" has been shown to be an important player in regulating many physiological and pathological processes. Meanwhile, the phenomenon of cancer drug resistance is becoming more and more frequent, especially in the case of cancer chemotherapy resistance. In recent years, research on relationship between post-transcriptional modification and cancer including drug resistance has become a hot topic, especially the methylation of the sixth nitrogen site of RNA adenosine-mA (N6-methyladenosine).
View Article and Find Full Text PDFSex differences in the metabolic activation of and platelet response to vicagrel in mice: Androgen as a key player.
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Division of Clinical Pharmacology, General Clinical Research Center, Nanjing First Hospital, China Pharmaceutical University, Nanjing 210006, China; Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China; Division of Clinical Pharmacology, General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China. Electronic address:
As a biological variable, sex influences the metabolism of and/or response to certain drugs. Vicagrel is being developed as an investigational new drug in China; however, it is unknown whether sex could affect its metabolic activation and platelet responsiveness. This study aimed to determine whether such differences could exist, and to elucidate the mechanisms involved.
View Article and Find Full Text PDFCandidate membrane protein gene families related to chemoreception in a wood-boring beetle, Pharsalia antennata Gahan (Coleoptera: Cerambycidae).
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Key Laboratory of Forest Disaster Warning and Control of Yunnan Province, Southwest Forestry University, Kunming 650224, China. Electronic address:
The longhorned beetles are key players for the maintenance of biodiversity in the terrestrial ecosystem. As xylophagous cerambycid insects in Coleoptera, the beetles have evolved specialized olfactory and gustatory systems to recognize chemical cues in the surrounding habitats. Despite over 36,000 described species in the Cerambycidae family including a wood-boring pest Pharsalia antennata, only a limited number of them (<1 %) have been characterized regarding their chemical ecology at the molecular level.
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