HLA-B*13:01:06 has one nucleotide acid change (G→A) at position 219, at codon 49 (GCG→GCA) in exon2 without amino acid change (Ala→Ala).
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http://dx.doi.org/10.1111/tan.12098 | DOI Listing |
Sci Rep
December 2024
School of Environmental Science, The University of Shiga Prefecture, Hassakacho, Hikone, 2500, 522-8533, Japan.
Mangrove forests are increasingly recognized as vital blue carbon ecosystems due to their high carbon sequestration capacity, primarily through the accumulation of soil organic carbon (SOC). Recent research highlights that, in addition to SOC, dissolved inorganic carbon (DIC), particularly in the form of bicarbonate (HCO₃⁻), plays a crucial role in carbon sequestration by being exported from these ecosystems to adjacent coastal waters. This study aims to investigate the previously unexamined mechanisms behind bicarbonate production in mangrove soils.
View Article and Find Full Text PDFNPJ Sci Food
December 2024
College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China.
Medium- and long-chain triacylglycerols (MLCTs) are regarded as healthy premium oils; however, the health benefits of novel MLCTs enriched with lauric and α-linolenic acids are still not fully understood. This study examined the health benefits of lauric-α-linolenic structural lipids (ALSL) and physical mixture (PM) with a similar fatty acid composition in mice with obesity induced by the high-fat diet (HFD). The data indicated that ALSL is more effective than PM in counteracting obesity, insulin resistance, hyperlipidaemia, liver injury, and systemic inflammation in HFD-induced mice.
View Article and Find Full Text PDFNat Commun
December 2024
Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Clade 2.3.4.
View Article and Find Full Text PDFJ Biomol Struct Dyn
February 2025
Laboratory of Integrative Genomics, Department of Integrative Biology, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT), Vellore, India.
The P53 protein, a cancer-associated transcriptional factor and tumor suppressor, houses a Zn ion in its DNA-binding domain (DBD), essential for sequence-specific DNA binding. However, common mutations at position 273, specifically from Arginine to Histidine and Cysteine, lead to a loss of function as a tumor suppressor, also called DNA contact mutations. The mutant (MT) P53 structure cannot stabilize DNA due to inadequate interaction.
View Article and Find Full Text PDFSmall
December 2024
Département de chimie, Université de Sherbrooke, Sherbrooke, QC, J1K 2R1, Canada.
A liquid crystal elastomer (LCE) actuator capable of colorimetric humidity sensing is realized. The designed LCE features acid protonated amino azobenzene side groups in its structure, which endow the actuator with the hygroscopicity and act as the humidity reporter via color changes. Given that the protonated and deprotonated chromophore absorb visible light at different wavelengths, when the protonated LCE is under higher humidity, it absorbs more water that deprotonates azobenzene and leads to a change in color.
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