Unlabelled: One of the methods for correction of "whistle" deformity following a primary bilateral cleft lip repair is a Skoog procedure. It consists of orbicularis oris muscle mobilization and suture following vermilion closure in a V-Y manner. The aim of the study was to evaluate late results of Skoog procedure in "whistle" deformity correction.
Material And Methods: Between 2000 and 2009 12 patients with whistle deformity underwent Skoog procedure. All of them were operated by the same surgeon. Aesthetic outcome in terms of lip fullness, symmetry and overall appearance was evaluated by patient and three independent examiners in four-point scale (1 - dissatisfied, 4 - very good). Pre- and postoperative vertical vermilion height was calculated bydigital analysis of photographs. in addition, complications and patient problems such as lip pain, microstomia, smiling or speech disturbances and scabbing of malpositioned wet vermilion were recorded.
Results: Six patients (4 men, 2 women, aged 23-44 years, mean 29 years) were included into the study. The average follow-up was 69.5 months. Patients higher evaluated overall appearance (mean 3.83) than symmetry (mean 3.16) and lip fullness (mean 3.16). Lip symmetry evaluated by independent examiners was assessed higher (mean 3.5) than overall appearance (mean 3.33) and lip fullness (mean 3). Digital analysis of photographs shows that mean vertical vermilion height increased after Skoog procedure from 34 to 142% (mean 71.5%). Besides acceptable scabbing of malpositioned wet vermilion no complications and patient problems occurred.
Conclusions: Skoog procedure provided a simple and reliable option for the correction of "whistle" deformity.
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Alzheimers Dement
December 2024
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Introduction: This study investigated the associations of brain age gap (BAG)-a biological marker of brain resilience-with life exposures, neuroimaging measures, biological processes, and cognitive function.
Methods: We derived BAG by subtracting predicted brain age from chronological age in 739 septuagenarians without dementia or neurological disorders. Robust linear regression models assessed BAG associations with life exposures, plasma inflammatory and metabolic biomarkers, magnetic resonance imaging, and cerebrospinal fluid biomarkers of neurodegeneration and vascular brain injury, and cognitive performance.
J Immunother Cancer
December 2024
Lund Stem Cell Center, Lund University, Lund, Sweden
Background: Pancreatic ductal adenocarcinoma (PDAC) represents a major clinical challenge due to its tumor microenvironment, which exhibits immune-suppressive properties that facilitate cancer progression, metastasis, and therapy resistance. Interleukin 1 (IL-1) signaling has been implicated as a driver in this process. Mechanistically, both IL-1α and IL-1β bind to the IL-1 receptor type 1, forming a complex with IL-1-receptor accessory protein (IL1RAP), which triggers downstream signaling pathways.
View Article and Find Full Text PDFClin Psychol Eur
September 2024
Department of Psychology, University of Gothenburg, Gothenburg, Sweden.
Clin Proteomics
December 2024
Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden.
Background: The effect of varying brain ventricular volume on the cerebrospinal fluid (CSF) proteome has been discussed as possible confounding factors in comparative protein level analyses. However, the relationship between CSF volume and protein levels remains largely unexplored. Moreover, the few existing studies provide conflicting findings, indicating the need for further research.
View Article and Find Full Text PDFNeuroradiol J
December 2024
Hydrocephalus Research Unit, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.
Purpose: Epidemiological studies on idiopathic normal pressure hydrocephalus (iNPH) imaging markers and their normal values are scarce. This population-based study aimed to analyze several morphologic and volumetric iNPH-related imaging markers in a large sample, determining their distribution, diagnostic accuracy, suggested cut-offs, and associations with iNPH symptoms.
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