Objective: To evaluate prospectively the value of the 'repositioning test' (RT) in preoperative patient selection for the efficacy of male stress urinary incontinence (SUI) treatment using a retroluminar transobturator male sling (AdVance sling).
Patients And Methods: 65 consecutive patients with SUI after radical prostatectomy were included in this single-center prospective study. Preoperatively, patients were classified into those with 'positive' and 'negative' RT. Postoperative results were analyzed and the association between the result of the RT and postoperative outcome was evaluated.
Results: 53 patients (81.5%) showed preoperatively a positive RT and 12 patients (18.5%) a negative RT. After a follow-up of 12 months, patients with positive RT showed a cure rate (0 pads/day) of 83% and patients with a negative RT showed only a cure rate of 25%. A positive RT significantly correlated with cure in outcome (p < 0.001).
Conclusions: Patients with positive RT have a significantly better chance for successful AdVance sling implantation. The RT is minimally invasive, easy to learn and easy to perform. Therefore, the RT is a very useful tool for preoperative patient selection.
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http://dx.doi.org/10.1159/000347123 | DOI Listing |
Pharmaceutics
January 2025
Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, 70125 Bari, Italy.
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View Article and Find Full Text PDFCurr Issues Mol Biol
January 2025
Amity Institute of Biotechnology, Amity University Rajasthan, SP-1, Kant Kalwar, RIICO Industrial Area, NH-11C, Jaipur 303002, Rajasthan, India.
Background: Colorectal cancer (CRC) is a complex and increasingly prevalent malignancy with significant challenges in its treatment and prognosis. This study aims to explore the role of the SLC4A4 transporter as a biomarker in CRC progression and its potential as a therapeutic target, particularly in relation to tumor acidity and immune response.
Methods: The study utilized computational approaches, including receptor-based virtual screening and high-throughput docking, to identify potential SLC4A4 inhibitors.
J Clin Orthop Trauma
March 2025
Department of Orthopaedics, Woodend Hospital, Aberdeen, AB15 6XS, UK.
Reverse shoulder arthroplasty (RSA) has witnessed a significant advancement with the introduction of lateralisation techniques, aiming to enhance shoulder function and implant durability. Traditional medialised designs, following Grammont's principles, have encountered challenges such as scapular notching, reduced rotational strength, and instability. In contrast, lateralisation methods, which reposition the joint center of rotation laterally on the glenoid, humerus, or both, seek to improve deltoid leverage, optimize the rotator cuff muscles' length-tension relationship, and enhance joint stability.
View Article and Find Full Text PDFGenome Med
January 2025
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA.
Background: Large-scale pharmacogenomic resources, such as the Connectivity Map (CMap), have greatly assisted computational drug discovery. However, despite their widespread use, CMap-based methods have thus far been agnostic to the biological activity of drugs as well as to the genomic effects of drugs in multiple disease contexts. Here, we present a network-based statistical approach, Pathopticon, that uses CMap to build cell type-specific gene-drug perturbation networks and integrates these networks with cheminformatic data and diverse disease phenotypes to prioritize drugs in a cell type-dependent manner.
View Article and Find Full Text PDFMedicine (Baltimore)
January 2025
Department of Otorhinolaryngology-Head & Neck Surgery, Daegu Catholic University Medical Center, Daegu, Korea.
Background: The Epley or Semont maneuver is performed for posterior canal benign paroxysmal positional vertigo (PC-BPPV). The postural crisis indicates the phenomenon that the patient experiences severe dizziness, is unable to maintain the sitting posture, and suddenly falls backward or sideways on the examination table when returning to the sitting position, which is the final step of the canalith repositioning procedure (CRP). The postural crisis increases the risk of falls during CRP.
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