Ganciclovir therapy in two immunocompetent infants with severe acquired CMV pneumonitis.

Cytomegalovirus (CMV) infection in immunocompetent hosts is usually benign and does not require antiviral therapy. Rarely, however, it can be severe and life-threatening. Two immunocompetent infants with severe acquired CMV infection are reported who responded dramatically to ganciclovir with no observed side-effects. Ganciclovir should be considered in the rare instance of severe CMV infection in immunocompetent children.